Infect Chemother.  2015 Jun;47(2):142-144. 10.3947/ic.2015.47.2.142.

Overexpression of Efflux Pump in Multiresistant Pseudomonas aeruginosa: How You Will Discover and Treat It?

• Koo SH

• KMID: 2069003
• DOI: http://doi.org/10.3947/ic.2015.47.2.142

Abstract

No abstract available.

MeSH Terms

Pseudomonas aeruginosa*

Reference

1. Harris A, Torres-Viera C, Venkataraman L, DeGirolami P, Samore M, Carmeli Y. Epidemiology and clinical outcomes of patients with multiresistant Pseudomonas aeruginosa. Clin Infect Dis. 1999; 28:1128–1133.

2. Putman M, van Veen HW, Konings WN. Molecular properties of bacterial multidrug transporters. Microbiol Mol Biol Rev. 2000; 64:672–693.

3. Poole K. Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms. J Mol Microbiol Biotechnol. 2001; 3:255–264.

4. Zavascki AP, Carvalhaes CG, Picão RC, Gales AC. Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistancemechanisms and implications for therapy. Expert Rev Anti Infect Ther. 2010; 8:71–93.

5. Dumas L, van Delden C, Perron K, Köhler T. Analysis of antibiotic resistance gene expression in Pseudomonas aeruginosa by quantitative real-time-PCR. FEMS Microbiol Lett. 2006; 254:217–225.

6. Shigemura K, Osawa K, Kato A, Tokimatsu I, Arakawa S, Shirakawa T, Fujisawa M. Association of overexpression of efflux pump genes with antibiotic resistance in-Pseudomonas aeruginosa strains clinically isolated from urinary tract infection patients. J Antibiot (Tokyo). 2015; [Epub ahead of print].

7. Jiang X, Zhang W, Zhang Y, Gao F, Lu C, Zhang X, Wang H. Assessment of efflux pump gene expression in a clinical isolate Mycobacterium tuberculosis by real-time reverse transcription PCR. Microb Drug Resist. 2008; 14:7–11.

8. Yasufuku T, Shigemura K, Shirakawa T, Matsumoto M, Nakano Y, Tanaka K, Arakawa S, Kinoshita S, Kawabata M, Fujisawa M. Correlation of overexpression of efflux pump genes with antibiotic resistance in Escherichia coli Strains clinically isolated from urinary tract infection patients. J Clin Microbiol. 2011; 49:189–194.

9. Adabi M, Talebi-Taher M, Arbabi L, Afshar M, Fathizadeh S, Minaeian S, Moghadam-Marageh N, Majidpour A. Spread of efflux pump overexpressing-mediated fluoroquinolone resistance and multidrug resistance in Pseudomonas aeruginosa by using an efflux pump inhibitor. Infec Chemother. 2015; 47:98–104.

10. Kriengkauykiat J, Porter E, Lomovskaya O, Wong-Beringer A. Use of an efflux pump inhibitor to determine the prevalence of efflux pump-mediatedfluoroquinolone resistance and multidrug resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2005; 49:565–570.

11. Askoura M, Mottawea W, Abujamel T, Taher I. Efflux pump inhibitors (EPIs) as new antimicrobial agents against Pseudomonas aeruginosa. Libyan J Med. 2011; 6:5870.