J Korean Neurol Assoc.  1991 Dec;9(4):418-424.

Clinical Values of Immunoglobulin in Cerebrospinal Fluid

• Park SP
• Lee YH
• Lim JG
• Lee DK
• Yi SD
• Park YC
• Suh CK

Abstract

We studied on 263 patients (20 with multiple sclerosis (MS); 243 with other neurological diseases (OND), I.e., 87 with myelopathy of unknown origin (MUO), 27 with central nervous system (CNS) infection, 31 with peripheral neuropathy (PN), 23 with cerebrovascular accident (CVA), and 75 with miscellaneous diseases (MD)), who were admitted to the Keimyung University Dongsan Hospital between January 1985 and April 1991 to analyze the clinical values of the cerebrospinal fluid (CSF) Ig G in MS and OND with quantitative CSF Ig G, Ig G-albumin ratio and Ig index by immunodiffusion method, and to detect oligoclonal bands in CSF of 21 patients (2 with MS, 15 with MUO, 1 with PN, 1 with CVA and 2 with MD) by agarose-gel electrophoresis. The results were summarized as follows: 1) In the frequency of elevated quantitative CSF Ig G measurements in patients with MS, the Ig G index was 64% (9 of 14 patients), higher than those of the Ig G and Ig G-albumin ratio, but in OND, the Ig G-albumin ratio was 30% (73 of 240 patients), higher than those of the Ig G and Ig G index. 2) In the frequencies of elevated quantitative CSF Ig G measurements, the Ig G levels in CNS infection, CVA and PN were 67%, 35% and 29%, respectivelyl higher than 25% in MS, and the Ig G-albumin ratio in CNS infection and CVA were 63% and 35%, respectively, higher than 32% in MS, but the Ig G index was the highest in MS (64%) followed by CNS infection (54%). 3) In validity of the various CSF Ig G measurements for diagnosis of MS, the Ig G index was the most sensitive test at 064, the Ig G was the most specific test at 0.76, and the Ig G index had the most positive and negative predictive values at 0.16 and 0.96, respectively. 4) Oligoclonal bands in CSF are not detected in all of 21 patients.

MeSH Terms

Central Nervous System
Cerebrospinal Fluid*
Diagnosis
Electrophoresis
Humans
Immunodiffusion
Immunoglobulins*
Multiple Sclerosis
Oligoclonal Bands
Peripheral Nervous System Diseases
Spinal Cord Diseases
Stroke
Immunoglobulins
Oligoclonal Bands