J Korean Geriatr Soc.  2011 Dec;15(4):234-239. 10.4235/jkgs.2011.15.4.234.

A Case of Demyelinating Peripheral Neuropathy Associated with Hashimoto's Thyroiditis

• Park JH
• Hong SM
• Lee CB
• Park YS
• Kim DS
• Choi WH
• Ahn YH

• KMID: 2064129
• DOI: http://doi.org/10.4235/jkgs.2011.15.4.234

Abstract

Peripheral neuropathy is somewhat common in hypothyroidism. But, demyelinating peripheral neuropathy in Hashimoto's thyroiditis is extremely rare. The pathophysiology of demyelinating peripheral neuropathy associated with Hashimoto's thyroiditis is unclear and complex and various mechanisms including the cell mediated and antibody mediated responses may be operative. We report a 68-year-old woman who presented with paresthesia and gait disturbance. She was diagnosed with hypothyroidism 7 years prior and has been on thyroid hormone. Serum antithyroglobulin antibody was significantly elevated. Nerve conduction studies revealed sensory-motor demyelinating polyneuropathy with prolonged distal latencies and reduced conduction velocities. She was under the suspicion of the lymphoma of thyroid. Surgery was performed which turned up to be Hashimoto's thyroiditis. With the impression of rare demyelinating peripheral neuropathy associated with Hashimoto's thyroiditis after other causes were excluded, she was treated with steroid which ameliorated rapidly her neurological symptoms.

Keyword

Hashimoto's thyroiditis; Polyradiculoneuropathy; Steroids

MeSH Terms

Aged
Autoantibodies
Female
Gait
Humans
Hypothyroidism
Lymphoma
Neural Conduction
Paresthesia
Peripheral Nervous System Diseases
Polyneuropathies
Polyradiculoneuropathy
Steroids
Thyroid Gland
Thyroiditis
Autoantibodies
Steroids