J Korean Endocr Soc.  2007 Aug;22(4):266-271. 10.3803/jkes.2007.22.4.266.

A Case of Turner's Syndrome with Transient Hypopituitarism

• Nam JS
• Cho MH
• Roh JM
• Kim HJ
• Yoon JE
• Jung HY
• Park JS
• Kang ES
• Ahn CW
• Cha BS
• Lee EJ
• Lim SK
• Kim KR
• Lee HC

• KMID: 2063536
• DOI: http://doi.org/10.3803/jkes.2007.22.4.266

Abstract

Turner's syndrome is characterized by short stature and gonadal dysgenesis, and it is often associated with various systemic manifestations, such as cardiovascular, renal, thyroidal, gastrointestinal, and musculoskeletal disorders. Though very rare, it can also be accompanied by hypopituitarism. It is important to give a meticulous medical attention to short females with gonadal dysgenesis so that neither disease is neglected or gets delayed diagnosis. In this case, Turner's syndrome and hypopituitarism were diagnosed almost simultaneously, but hypopiuitarism was transient, and the normal pituitary function was recovered spontaneously without any treatment. Initial sella MRI showed mild congenital hypoplastic hypopituitarism, and combined pituitary function test was compatible with hypopituitarism, but after 5 years, though growth hormone deficiency was still present, otherwise normal pituitary function was noted without any change in MRI. Herein, we are reporting a case of Turner's syndrome with transient idiopathic hypopituitarism with the review of literature.

Keyword

Growth hormone deficiency; Transient hypopituitarism; Turner's syndrome

MeSH Terms

Delayed Diagnosis
Female
Gonadal Dysgenesis
Growth Hormone
Humans
Hypopituitarism*
Magnetic Resonance Imaging
Pituitary Function Tests
Thyroid Gland
Turner Syndrome*
Growth Hormone

Figure

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  Fig. 1 The patient has karyotype of 45,X/46,XX.

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  Fig. 2 Sella dynamic MRI (2001.4.8). Mild, diffuse shrinkage of pituitary gland with slightly upward displacement and reduced size of neurohypophysis is seen, compatible with congenital hypoplasitc hypopituitarism.

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  Fig. 3 Sella dynamic MRI (2006.10.13). No remarkable interval change of pituitary gland size and shape on this study. Mild hypoplastic pituitary gland is suggested.

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