Korean J Urol.  2007 Sep;48(9):927-932. 10.4111/kju.2007.48.9.927.

The Prognostic Significance of Elevated Serum Creatinine for the Recurrence and Progression in Superficial Bladder Tumors

• Joo JS
• Kim JS
• Jung SI
• Kang TW
• Kwon DD
• Choi C
• Park KS
• Ryu SB

• KMID: 2061293
• DOI: http://doi.org/10.4111/kju.2007.48.9.927

Abstract

PURPOSE
There are many prognostic indicators of bladder tumors including clinical, pathological and molecular markers based on tumor-related factors. This study was performed to evaluate the significance of an elevated level of serum creatinine for predicting progression and recurrence of superficial bladder tumors.
MATERIALS AND METHODS
One hundred forty-seven patients that initially presented with a superficial bladder tumor(pTa or pT1) except for a carcinoma in situ were retrospectively analyzed according to several factors such as tumor stage, grade, size, multiplicity and serum creatinine for tumor recurrence and progression after a primary transurethral resection.
RESULTS
The elevated serum creatinine group consisted of 20 patients 11 patients experienced recurrence(55.0%) and 3 patients experienced progression(15.0%). The control group consisted of 127 patients 39 patients experienced recurrence(30.7%) and 13 patients experienced progression (10.2%). The presence of an elevated level of serum creatinine and tumor multiplicity were statistically significant prognostic factors for tumor recurrence.
CONCLUSIONS
These results can be helpful for predicting the prognosis of transitional cell carcinoma of the bladder and for planning therapeutic and follow-up strategies.

Keyword

Urinary bladder neoplasms; Prognosis; Creatinine

MeSH Terms

Carcinoma in Situ
Carcinoma, Transitional Cell
Creatinine*
Follow-Up Studies
Humans
Prognosis
Recurrence*
Retrospective Studies
Urinary Bladder Neoplasms*
Urinary Bladder*
Creatinine

Reference

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