A Patho-histologic Study on Experimental Sperm Granuloma

Lee, Hee Choon

Abstract

As Glassy and Mostofi stated, sperm granuloma is not rarely encountered in clinical practice and more cases are expected to occur due to practical vasectomy for family planning. Incomplete ligation after vasectomy or increased intraluminal pressures of vas deferens after vasectomy seems to predispose sperm granuloma. However, it is hard to review in literature to understand on its exact etiological mechanism and histologic picture of the lesion. The author has selected male albino rats and divided into 3 groups. Group I only ligation of the vas, group 2 vasectomy and ligation and group 3 vasectomy only without ligation. Gross and microscopic findings after 4 weeks were as following; 1. Pathologic lesions were noted in each experiment group. 2. Pathologic lesions were more frequently noted in group 2 and 3 than group 1. 3. The size of the pathologic lesion was larger in group 3 than group 1 or 2. 4. Pathologic lesion in group 1 or 2 was due to distention of the lumen due to increased intraluminal pressure and that of group 3 was due to leakage of the sperm into the surrounding soft tissue. 5. Pathologic lesions noted in this experiment was similar to those of human sperm granuloma.