J Korean Acad Fam Med.
2007 Nov;28(11):853-859.
The Cognitive Subscale of Alzheimer's Disease Assessment Scale (ADAS-Cog) for Patients with Alzheimer's Disease in Korea
- Affiliations
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- 1Department of Family Medicine, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 2Department of Neuropsychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 3Department of Family Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. juana@catholic.ac.kr
Abstract
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BACKGROUND: This study was designed to examine the utility of the ADAS-Cog, Korean version (ADAS-K-cog) for staging of dementia in Alzheimer disease (AD). We also studied the possible influence of age, sex, and education on a ADAS-K-cog.
METHODS
A total of 70 patients with AD meeting the NINCDS-ADRDA criteria of probable AD were recruited. The ADAS-K-cog was administered to all AD subjects. Each patient was also rated on the Global Deterioration Scale (GDS). The probable AD patients were divided into three groups based on their GDS stage to evaluate the sensitivity of ADAS-K-cog to disease severity and their mean scores on ADAS-K-cog were compared.
RESULTS
The subjects' age range was 65~93 years and their education range was 0~16 years. The total score of ADAS-K-cog and each item score differed significantly between each groups. The item score of orientation, expressive language, word finding difficulty, comprehension of spoken language and the ADAS-K-cog total score could classify severity of early AD patients efficiently. ADAS-K-cog had high correlations with scores on the GDS (Pearson's r=0.732) and the Mini-Mental State Examination (Pearson's r=-0.755). Multiple regression analysis revealed that performance on the Korean ADAS- Cog was uninfluenced by age or gender, and neither by education level. It's language items were best for monitoring the progression of dementia.
CONCLUSION
Our results indicated that the ADAS-K-cog is useful for staging of AD and uninfluenced by education level, sex and age.
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