J Gynecol Oncol.  2009 Mar;20(1):44-47. 10.3802/jgo.2009.20.1.44.

Fertility preservation in patients with early epithelial ovarian cancer

  • 1Department of Obstetrics and Gynecology, College of Medicine, Kwandong University, Cheil General Hospital and Women's Healthcare Center, Seoul, Korea. kbongchun@hanmail.net


To assess the role of fertility preservation in the treatment of patients with early epithelial ovarian cancer (EOC).
We retrospectively analyzed the medical records of 21 patients with early EOC from January 1995 to December 2006. All eligible patients with a strong desire to preserve fertility were younger than 35 years and underwent fertility-sparing surgery with or without adjuvant chemotherapy.
Twenty-one eligible patients with a median age of 26.7 years (range, 20 to 33 years) were identified, and the mean follow-up period was 43 months (range, 5 to 86 months). Only one patient with stage IC recurred 34 months after the first operation. A total of five patients were able to become pregnant at least once after the first fertility preserving treatment, with or without adjuvant chemotherapy. All five patients succeeded in full-term vaginal delivery with healthy infants. No patients died of their disease.
Fertility preserving treatment in patients with early EOC can be considered as a proper treatment strategy in patients with early EOC, who have the strong desire for fertility preservation.


Fertility preservation; Epithelial ovarian cancer; Staging operation

MeSH Terms

Chemotherapy, Adjuvant
Fertility Preservation
Follow-Up Studies
Medical Records
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
Retrospective Studies
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms

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1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, et al. Cancer statistics, 2006. CA Cancer J Clin. 2006. 56:106–130.
2. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics, 2001. CA Cancer J Clin. 2001. 51:15–36.
3. Duska LR, Chang YC, Flynn CE, Chen AH, Goodman A, Fuller AF, et al. Epithelial ovarian carcinoma in the reproductive age group. Cancer. 1999. 85:2623–2629.
4. Plaxe SC, Braly PS, Freddo JL, McClay E, Kirmani S, Howell SB. Profiles of women age 30-39 and age less than 30 with epithelial ovarian cancer. Obstet Gynecol. 1993. 81:651–654.
5. Rodriguez M, Nguyen HN, Averette HE, Steren AJ, Penalver MA, Harrison T, et al. National survey of ovarian carcinoma XII. Epithelial ovarian malignancies in women less than or equal to 25 years of age. Cancer. 1994. 73:1245–1250.
6. Swenerton KD, Hislop TG, Spinelli J, LeRiche JC, Yang N, Boyes DA. Ovarian carcinoma: a multivariate analysis of prognostic factors. Obstet Gynecol. 1985. 65:264–270.
7. Smedley H, Sikora K. Age as a prognostic factor in epithelial ovarian carcinoma. Br J Obstet Gynaecol. 1985. 92:839–842.
8. Piver MS, Barlow JJ, Lele SB. Incidence of subclinical metastasis in stage I and II ovarian carcinoma. Obstet Gynecol. 1978. 52:100–104.
9. Chen SS, Lee L. Incidence of para-aortic and pelvic lymph node metastases in epithelial carcinoma of the ovary. Gynecol Oncol. 1983. 16:95–100.
10. Burghardt E, Girardi F, Lahousen M, Tamussino K, Stettner H. Patterns of pelvic and paraaortic lymph node involvement in ovarian cancer. Gynecol Oncol. 1991. 40:103–106.
11. Cass I, Li AJ, Runowicz CD, Fields AL, Goldberg GL, Leuchter RS, et al. Pattern of lymph node metastases in clinically unilateral stage I invasive epithelial ovarian carcinomas. Gynecol Oncol. 2001. 80:56–61.
12. Young RC, Walton LA, Ellenberg SS, Homesley HD, Wilbanks GD, Decker DG, et al. Adjuvant therapy in stage I and stage II epithelial ovarian cancer: Results of two prospective randomized trials. N Engl J Med. 1990. 322:1021–1027.
13. NIH Consensus Development Panel on Ovarian Cancer. NIH consensus conference: Ovarian cancer. Screening, treatment, and follow-up. JAMA. 1995. 273:491–497.
14. Le T, Krepart GV, Lotocki RJ, Heywood MS. Clinically apparent early stage invasive epithelial ovarian carcinoma: Should all be treated similarly? Gynecol Oncol. 1999. 74:252–254.
15. Colombo N, Chiari S, Maggioni A, Bocciolone L, Torri V, Mangioni C. Controversial issues in the management of early epithelial ovarian cancer: conservative surgery and role of adjuvant therapy. Gynecol Oncol. 1994. 55(3 Pt 2):S47–S51.
16. Zanetta G, Chiari S, Rota S, Bratina G, Maneo A, Torri V, et al. Conservative surgery for stage I ovarian carcinoma in women of childbearing age. Br J Obstet Gynaecol. 1997. 104:1030–1035.
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