Hanyang Med Rev.  2009 Nov;29(4):379-385. 10.7599/hmr.2009.29.4.379.

Neurodevelopmental Outcomes of Extremely Preterm Infants

• Lee YK

• KMID: 2053725
• DOI: http://doi.org/10.7599/hmr.2009.29.4.379

Abstract

Recently, advances in perinatal and neonatal intensive care during the last decades have led to a dramatic increased survival of extremely preterm and extremely low birth weight infants (ELBWI, <1,000 g). These have influenced the rates of neonatal morbidity and neurodevelopmental impairment. Neurodevelopmental outcome is being used as the most important measure of successful neonatal care and has to be assessed, not only in the short term, but also in the long term. Long-term follow-up of ELBWI is necessary to identify neurodevelopmental outcomes with a wide array from major neurosensory disability to high prevalence/ low severity dysfunction in early childhood, school age and young adulthood.

Keyword

Neurodevelopmental outcome; Extremely preterm; Extremely low birth weight infants

MeSH Terms

Follow-Up Studies
Humans
Infant
Infant, Extremely Premature
Infant, Low Birth Weight
Infant, Newborn
Intensive Care, Neonatal

Reference

1. Fanaroff AA, Stoll BJ, Wright LL, Carlo WA, Ehrenkranz RA, Stark AR, Bauer CR, Donovan EF, Korones SB, Laptook AR, Lemons JA, Oh W, Papile LA, Shankaran S, Stevenson DK, Tyson JE, Poole WK. NICHD Neonatal Research Network. Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol. 2007; 196:147.e1–147.e8.

2. Kim KS, Bae CW. Trends in survival rate for very low birth weight infants and extremely low birth weight infants in Korea, 1967-2007. Korean J Pediatr. 2008; 51:237–242.

3. Wilson-Costello D, Friedman H, Minich N, Siner B, Taylor G, Schluchter M, Hack M. Improved neurodevelopmental outcomes for extremely low birth weight infants in 2000-2002. Pediatrics. 2007; 119:37–45.

4. Jeon GW, Kim MJ, Kim SS, Shim JW, Chang YS, Park WS, Lee MH. Improved survival rate with decreased neurodevelopmental disability in extreme immaturity. Korean J Pediatr. 2007; 50:1067–1071.

5. Vohr BR, Wright LL, Dusick AM, Mele L, Verter J, Steichen JJ, Simon NP, Wilson DC, Broyles S, Bauer CR, Delaney-Black V, Yolton KA, Fleisher BE, Papile LA, Kaplan MD. Neurodevelopmental and functional outcomes of extremely low birth weight infants in the national institute of child health and human development neonatal research network, 1993-1994. Pediatrics. 2000; 105:1216–1226.

6. Robertson C, Sauve RS, Christianson HE. Provincebased study of neurologic disability among survivors weighing 500 through 1,249 grams at birth. Pediatrics. 1994; 93:636–640.

7. Hack M, Friedman H, Fanaroff AA. Outcomes of extremely low birth weight infants. Pediatrics. 1996; 98:931–937.

8. Jacobs SE, O'Brien K, Inwood S, Kelly EN, Whyte HE. Outcome of infants 23-26 weeks' gestation pre and post surfactant. Acta Paediatr. 2000; 89:959–965.

9. Park MR, Lee BS, Kim EA, Kim KS, Pi SY. Outcomes of Extremely Low Birth Weight Infants at the Asan Medical Center between 2003 and 2006. J Korean Soc Neonatol. 2008; 15:123–133.

10. Wood NS, Marlow N, Costeloe K, Gibson AT, Wilkinson AR. Neurologic and developmental disability after extremely preterm birth. N Engl J Med. 2000; 343:378–384.

11. Kilbride HW, Thorstad K, Daily DK. Preschool outcome of less than 801-gram preterm infants compared with full-term siblings. Pediatrics. 2004; 113:742–747.

12. Emsley HC, Wardle SP, Sims DG, Chiswick ML, D'Souza SW. Increased survival and deteriorating developmental outcome in 23 to 25 week old gestation infants, 1990-4 compared with 1984-9. Arch Dis Child Fetal Neonatal Ed. 1998; 78:F99–F104.

13. Salokorpi T, Rautio T, Sajaniemi N, Serenius-Sirve S, Tuomi H, von Wendt L. Neurological development up to the age of four years of extremely low birthweight infants born in Southern Finland in 1991-94. Acta Paediatr. 2001; 90:218–221.

14. Mikkola K, Ritari N, Tommiska V, Salokorpi T, Lehtonen L, Tammela O, Paakkonen L, Olsen P, Korkman M, Fellman V. Neurodevelopmental outcome at 5 years of age of a national cohort of extremely low birth weight infants who were born in 1996-1997. Pediatrics. 2005; 116:1391–1400.

15. Hintz SR, Kendrick DE, Vohr BR, Poole WK, Higgins RD. NICHD Neonatal Research Network. Changes in Neurodevelopmental outcomes at 18 to 22 months' corrected age among infants of less than 25 weeks' gestational age born in 1993-1999. Pediatrics. 2005; 115:1645–1651.

16. Wilson-Costello D. Is there evidence that long-term outcomes have improved with intensive care? Semin Fetal Neonatal Med. 2007; 12:344–354.

17. Tran U, Gray PH, O'Callaghan MJ. Neonatal antecedents for cerebral palsy in extremely preterm babies and interaction with maternal factors. Early Hum Dev. 2005; 81:555–561.

18. Vohr BR, Wright LL, Dusick AM, Perritt R, Poole WK, Tyson JE, Steichen JJ, Bauer CR, Wilson-Costello DE, Mayes LC. Neonatal Research Network. Center differences and outcomes of extremely low birth weight infants. Pediatrics. 2004; 113:781–789.

19. Whitfield MF, Grunau RV, Holsti L. Extremely premature (< or = 800 g) schoolchildren: multiple areas of hidden disability. Arch Dis Child Fetal Neonatal Ed. 1997; 77:F85–F90.

20. Horwood LJ, Mogridge N, Darlow BA. Cognitive, educational, and behavioural outcomes at 7 to 8 years in a national very low birthweight cohort. Arch Dis Child Fetal Neonatal Ed. 1998; 79:F12–F20.

21. Buck GM, Msall ME, Schisterman EF, Lyon NR, Rogers BT. Extreme prematurity and school outcomes. Paediatr Perinat Epidemiol. 2000; 14:324–331.

22. Anderson P, Doyle LW. Neurobehavioral outcomes of school-age children born extremely low birth weight of very preterm in the 1990s. JAMA. 2003; 289:3264–3272.

23. Saigal S, den Ouden L, Wolke D, Hoult L, Paneth N, Streiner DL, Whitaker A, Pinto-Martin J. School-age outcomes in children who were extremely low birth weight from four international population-based cohorts. Pediatrics. 2003; 112:943–950.

24. Hack M, Taylor HG, Drotar D, Schluchter M, Cartar L, Andreias L, Wilson-Costello D, Klein N. Chronic conditions, functional limitations, and special health care needs of school-aged children born with extremely low-birth-weight in the 1990s. JAMA. 2005; 294:318–325.

25. Marlow N, Wolke D, Bracewell MA, Samara M. EPICure Study Group. Neurologic and developmental disability at six years of age after extremely preterm birth. N Engl J Med. 2005; 352:9–19.

26. Hille ET, den Ouden AL, Saigal S, Wolke D, Lambert M, Whitaker A, Pinto-Martin JA, Hoult L, Meyer R, Feldman JF, Verloove-Vanhorick SP, Paneth N. Behavioural problems in children who weigh 1000g or less at birth in four countries. Lancet. 2001; 357:1641–1643.

27. Hack M, Taylor HG, Schluchter M, Andreias L, Drotar D, Klein N. Behavioral outcomes of extremely low birth weight children at age 8 years. J Dev Behav Pediatr. 2009; 30:122–130.

28. Hack M, Cartar L, Schluchter M, Flannery D, Klein N. Poorer outcomes of extremely low birth weight (ELBW, <1kg) young adults. Pediatr Res. 2004; 55:504a.

29. Grunau RE, Whitfield MF, Fay TB. Psychosocial and academic characteristics of extremely low birth weight (≤800 g) adolescents who are free of major impairment compared with term-born control subjects. Pediatrics. 2004; 114:e725–e732.

30. Lefebvre F, Mazurier E, Tessier R. Cognitive and educational outcomes in early adulthood for infants weighing 1000 grams or less at birth. Acta Paediatr. 2005; 94:733–740.

31. Saigal S, Stoskopf B, Streiner D, Boyle M, Pinelli J, Paneth N, Goddeeris J. Transition of extremely low-birth-weight infants from adolescence to young adulthood: comparison with normal birth-weight controls. JAMA. 2006; 295:667–675.

32. Saigal S, Stoskopf B, Boyle M, Paneth N, Pinelli J, Streiner D, Goddeeris J. Comparison of current health, functional limitations, and health care use of young adults who were born with extremely low birth weight and normal birth weight. Pediatrics. 2007; 119:e562–e573.

33. Hack M, Youngstrom EA, Cartar L, Schluchter M, Taylor HG, Flannery D, Klein N, Borawski E. Behavioral outcomes and evidence of psychopathology among very low birth weight infants at age 20 years. Pediatrics. 2004; 114:932–940.

34. Hack M, Flannery DJ, Schluchter M, Cartar L, Borawski E, Klein N. Outcomes in young adulthood for very-low-birth-weight infants. N Engl J Med. 2002; 346:149–157.

35. Hack M. Young adult outcomes of very-low-birth-weight children. Semin Fetal Neonatal Med. 2006; 11:127–137.