Obstet Gynecol Sci.  2014 Sep;57(5):401-404. 10.5468/ogs.2014.57.5.401.

Endometrial carcinoma arising in a bicornuate uterus

• Munkhdelger J
• Mia-Jan K
• Cha DS
• Eom M

• KMID: 2051723
• DOI: http://doi.org/10.5468/ogs.2014.57.5.401

Abstract

Endometrial carcinomas arising in a bicornuate uterus are rare, only five case of which have been previously reported. We present a case of endometrial cancer arising in a bicornuate uterus, occurring in a 65-year-old woman. Unlike previously reported cases, our case showed mixed endometrial adenocarcinoma and undifferentiated carcinoma in one horn and focal adenocarcinoma in the other. Adequate tissue sampling of both horns is necessary for accurate diagnosis of malignancy in patients with a bicornuate uterus. Physicians should be aware of the possibility of this abnormality in cases when endometrial cancer is suspected but histology fails to confirm.

Keyword

Bicornuate uterus; Carcinoma; Endometrial neoplasms

MeSH Terms

Adenocarcinoma
Aged
Animals
Carcinoma
Diagnosis
Endometrial Neoplasms*
Female
Horns
Humans
Uterus*

Figure

• 

  Fig. 1 The gross appearance of a bicornuate uterus. (A) External surface of the bicornuate uterus. (B) On opening, the endometrium of left horn shows diffuse granular polypoid mass. Microscopic findings of the case. (C) Microscopic findings of mixed endometrioid adenocarcinoma (left) and undifferentiated carcinoma (right) of left horn. (D) A tiny focus of endometrioid adenocarcinoma in right horn (H&E, ×100).

• 

  Fig. 2 The immunohistochemical profiles. Endometrioid adenocarcinoma (left) and undifferentiated carcinoma (right). (A) Cytokeratin, (B) EMA, (C) estrogen receptor, (D) progesterone receptor, (E) CAM 5.2, and (F) p63 (×100).

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