Clin Exp Otorhinolaryngol.  2010 Dec;3(4):207-211. 10.3342/ceo.2010.3.4.207.

Optimal Continuous Positive Airway Pressure Level in Korean Patients with Obstructive Sleep Apnea Syndrome

• Choi JH
• Kim EJ
• Kim KW
• Choi J
• Kwon SY
• Lee HM
• Kim TH
• Lee SH
• Shin C
• Lee SH

• KMID: 2049053
• DOI: http://doi.org/10.3342/ceo.2010.3.4.207

Abstract

OBJECTIVES
The aim of this study was to investigate optimal continuous positive airway pressure (CPAP) level, to examine the factors affecting optimal CPAP level, and to develop a predictive equation for optimal CPAP level in Korean patients with obstructive sleep apnea syndrome (OSAS).
METHODS
A total of 202 patients with OSAS who underwent successful manual titration for CPAP treatment were included in this study. Correlations between the optimal CPAP level and baseline data including anthropometric and polysomnographic variables were analyzed. A predictive equation for optimal CPAP level was developed based on anthropometric and polysomonographic data.
RESULTS
The mean optimal CPAP level in 202 patients with OSAS was 7.8+/-2.3 cm H2O. The mean optimal CPAP level in the mild, moderate, and severe OSAS groups was 6.0+/-1.3, 7.4+/-1.9, and 9.1+/-2.1 cm H2O, respectively. The apneahypopnea index (AHI) (r=0.595, P<0.001), arousal index (r=0.542, P<0.001), minimal SaO2 (r=-0.502, P<0.001), body mass index (BMI) (r=0.494, P<0.001), neck circumference (r=0.265, P<0.001), and age (r=-0.164, P=0.019) were significantly correlated with optimal CPAP level. The best predictive equation according to stepwise multiple linear regression analysis was: Optimal CPAP level (cm H2O)=0.681+(0.205xBMI)+(0.040xAHI). Forty-two percent of the variance in the optimal CPAP level was explained by this equation (R2=0.42, P<0.001).
CONCLUSION
A predictive equation for optimal CPAP level in Korean patients with OSAS was developed using AHI and BMI, which can be easily measured during the diagnostic process.

Keyword

Obstructive sleep apnea syndrome; Continuous positive airway pressure; Polysomnography; Body mass index

MeSH Terms

Arousal
Body Mass Index
Continuous Positive Airway Pressure
Humans
Linear Models
Neck
Polysomnography
Sleep Apnea, Obstructive

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