Ann Lab Med.  2015 Jul;35(4):463-465. 10.3343/alm.2015.35.4.463.

Concurrent Hematologic and Metastatic Epithelial Malignancies in the Bone Marrow: Report of Three Cases

• Chang J
• Cho YU
• Cho EJ
• Jang S
• Seo EJ
• Huh J
• Park CJ

• KMID: 2045872
• DOI: http://doi.org/10.3343/alm.2015.35.4.463

Abstract

No abstract available.

MeSH Terms

Bone Marrow*

Figure

• 

  Fig. 1 Bone marrow (BM) findings and tissue preparations for patients. (A) Leukemic myeloblasts on BM aspirate smear with clusters of atypical cells from case 1 (Wright-Giemsa stain, ×1,000); (B) Cancerous cells that were positive for thyroid transcription factor-1 (TTF-1) (TTF-1 stain, ×400) and myeloperoxidase-positive myeloblasts of the mediastinal lymph node aspirate in case 1 (myeloperoxidase stain, ×400). (C) Prominent dyserythropoiesis (multinucleation) and atypical cell clusters on BM aspirate smear (Wright-Giemsa stain, ×1,000) and the BM biopsy infiltrated by cytokeratin 7-positive carcinoma cells (inset) in case 2 (cytokeratin 7 stain, ×200); (D) Excess of plasma cells and clusters of atypical cells on BM aspirate smear (Wright-Giemsa stain, ×1,000) and cancerous BM infiltrate with pan-cytokeratin positivity (inset) in case 3 (pan-cytokeratin stain, ×400).

Reference

1. Demandante CG, Troyer DA, Miles TP. Multiple primary malignant neoplasm: case report and a comprehensive review of the literature. Am J Clin Oncol. 2003; 26:79–83. PMID: 12576929.

2. Bahrami A, Truong LD, Ro JY. Undifferentiated tumor: true identity by immunohistochemistry. Arch Pathol Lab Med. 2008; 132:326–348. PMID: 18318577.

3. Molenaar RJ, Radivoyevitch T, Maciejewski JP, van Noorden CJ, Bleeker FE. The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation. Biochim Biophys Acta. 2014; 1846:326–341. PMID: 24880135.

4. Agarwal R, Gupta R, Bhaskar A, Sharma A, Thulkar S, Kumar L. Synchronous presentation of multiple myeloma and lung cancer. J Clin Oncol. 2008; 26:5814–5816. PMID: 19001336.

5. Perunicic-Jovanovic M, Djunic I, Tomin D, Terzic T, Jakovic L, Sokic A, et al. Simultaneous presentation of hairy cell leukemia and metastatic signet ring carcinoma of the stomach diagnosed by bone marrow biopsy. Appl Immunohistochem Mol Morphol. 2011; 19:279–282. PMID: 21475041.