Korean J Anesthesiol.  2006 Oct;51(4):455-462. 10.4097/kjae.2006.51.4.455.

Inhibiting Effect of Amiodarone to Protective Action against Ischemia/Reperfusion Injury Induced by Ischemic Preconditioning

• Koo EH
• Park CG
• Lim SH
• Park YC

• KMID: 2045364
• DOI: http://doi.org/10.4097/kjae.2006.51.4.455

Abstract

odarone. Isovolumetric left ventricular end systolic pressure (LVESP), left ventricular end diastolic pressure (LVEDP), dP/dtMAX and heart rate were measured.
RESULTS
Group II showed more recovered LVESP, less developed ventricular stiffness, more preserved coronary effluent flow, earlier termination of arrhythmia and smaller infarct size than Group I. Group III showed preserved LVESP and dP/dtMAX, less developed ventricular stiffness, shortest arrhythmia sustaining time, smallest infarct size among all groups. These myocardial protective effects were abolished in Group IV.
CONCLUSIONS
We observed that IPC and amiodarone administration, each has myocardial protective effects against myocardial ischemia, but when they are dealt at the same time, their beneficial effects diminished.

Keyword

amiodarone; ischemic preconditioning; isolated heart; myocardial protection; reperfusion arrhythmia

MeSH Terms

Amiodarone*
Arrhythmias, Cardiac
Blood Pressure
Heart Rate
Ischemic Preconditioning*
Myocardial Ischemia
Amiodarone