J Korean Neurosurg Soc.  1972 Oct;1(1):125-131.

Research Works of Cerebral Edema

• Lee IS

Abstract

So a considerable amount of work on the cerebral edema has been done by numerous investigator hat it is difficult to summarize the research works of cerebral edema on this paper. Cerebral edema is a well-recognized clinical entity. It was also quite obvious around many cerebral tumors and injured brains of the post-mortem materials. Further, in 1937, Stewart-Wallace considered that the fluid increase of the cerebral edema was in the intercellular or interstitial space. This was accepted by histologic using the light microscope and biochemists for the next two decades. Since 1957 electron microscope has been used to study, the concept of cerebral edema has been changes. So the author selected and introduced the following experimental studies and their occlusions from number of different clinical and experimental research works of cerebral edema that have been carried out since 1957. 1) Cold induced cerebral edema. 2) Experimental cerebral swelling produced by supratentorial extradural compression (implanted balloons). 3) Triethyltin-induced cerebral edema. 4) Cerebral edema due to implantation of foreign substances. 5) Cerebral edema associated with experimental intracerebal tumors. 6) Experimental ischemic brain swelling and experimental intracranial hypertension due toe vascular blockade. 7) Ouabeininduced cerebral edema. 8) Serotonin-induced cerebral edema. 9) Cerebral edema due to radiofrequency lesion. 10) The effect of laser irradiation. By these experimental cerebral edema numerous conclusions were reported, but the important results were as follows: 1) In the cortex there is enlargement of astrocytes. 2) Axonal and myeline changes occur. 3) Ultrastuructural studies indicate that edema was entirely intracellular. 4) Basically cerebral edema is an extracellular phenomenon of the white matter accompanied by marked swelling of the astrocytes. 5) An increase in water and sodium and decrease in potassium content of white matter, resulting in a sharp rise of Na: K ratio is evident. 6) Radioactive amino acid incorporation into protein of edematous brain is increased. 7) The depressed respiratory control, depressed P:O radio and accelerated state 4 respiration are present. Moreover, it has become apparent that these are some disadvantages in the experimentally induced cerebral edema. It may not involve the entire brain uniformly: different agents produce different types of edema; patterns are subject to variations of animal species and cerebral topography; the extent of damage is not controllable and reproducible; consistency of damage is uncertain no all experimental edema are artificial and not completely analogous to those occurring in human pathology. Nonetheless, cold induced edema and extradural compression method can be considered as a prototype of traumatic brain swelling. And the experimental intracerebral tumors can be exact counterparts in human pathology also. The laser irradiation and radio frequency lesion can produce standardized lesion and edema, further they will be appreciable to study the efficacy of various agents in reducing intracranial damage and edema.

MeSH Terms

Animals
Astrocytes
Axons
Brain
Brain Edema*
Edema
Humans
Intracranial Hypertension
Myelin Sheath
Pathology
Potassium
Research Personnel
Respiration
Sodium
Toes
Water
Potassium
Sodium
Water