Nephrotic Syndrome in Venous Thrombosis

Jung, Suk In; Choi, Sang Yong; Whang, Cheung Wung

Abstract

The overall incidence per year of deep vein thrombosis is about one per thousand in western, but may be much higher in the presence of certain clinical risk factors such as advanced age, immobilization, surgical procedures, pregnancy, puerperium, use of oral contraceptive agents and malignancy. Moreover, homocystinuria, nephrotic syndrome, systemic lupus erythematosus and hematological disorders such as paroxysmal nocturnal hemoglobinuria or myeloproliferative syndromes predispose to thrombotic disease. Evaluation of the patient with thromboembolism should include detailed history, clinical examination and laboratory investigation to exclude these secondary thrombophilic states. Nephrotic syndrome is characterized by albuminuria, hypoalbuminuria, hyperlipidemia and edema. The thromboembolic complications of nephrotic syndrome are reasonably common, including spontaneous peripheral venous or arterial , pulmonary arterial, and renal venous occlusions. For this study, we had elected 7 cases of deep vein thrombosis which were performed admitted at Korea University Hospital between 1991 to 1996. Among 7 cases, 6 cases were occluded at iliofemoral vein and I case was occluded ar renal vein. They were treated with heparin and warfarin. In conclusion, in deep vein thrombosis, we have to search other casuse of deep vein thrombosis such as nephrotic syndrome