Korean J Anesthesiol.  1994 Mar;27(3):246-250. 10.4097/kjae.1994.27.3.246.

Benefits of Bilateral Isolated Forearm Techinique to study the neuromuscular blockade

• Kim SY
• Hwang KH
• Ok SY
• Kim SI
• Ahn KR
• Kim SC
• Park W

• KMID: 2040009
• DOI: http://doi.org/10.4097/kjae.1994.27.3.246

Abstract

This technique in the conscious volunteers to study the neuromuscular blockade was described in which two different muscle relaxants of ED95X10(-1) in 20ml 0.9% saline were injected simultaneously into one arm and the contralateral arm below the occlusion site of circulation with tourniquet, and then two different neuromuscular blockades were compared following tourniquet released after 80% twitch depression. The benefits of this technique were obtained as following; 1) Simplicity, saving and safety from easily to set up and using low dose of muscle relaxant. 2) Expected results from pure effects of muscle relaxant without any drug interactions. 3) Time shortening of experimental study. 4) Saving time and experiments from simultaneously comparison of control with study group in one experiment. 5) The study of pure receptor binding with muscle relaxant, since a presumed plasma concentration of muscle relaxants is near or actually zero after release of the tourniquet when fresh blood had flushed the limb. Conclusively bilateral isolated forearm technique is elegant method to study the biophase binding interacted of relaxants and cholinerceptor.

Keyword

Isolated forearm technique; Neuromuscular blocking agents; Biophase binding

MeSH Terms

Arm
Depression
Drug Interactions
Extremities
Forearm*
Neuromuscular Blockade*
Neuromuscular Blocking Agents
Plasma
Tourniquets
Volunteers
Neuromuscular Blocking Agents