Korean Circ J.  2012 May;42(5):345-348. 10.4070/kcj.2012.42.5.345.

Recurrent Deep Vein Thrombosis due to Thrombophilia

• Rahman A
• Islam AM
• Husnayen S

• KMID: 2028764
• DOI: http://doi.org/10.4070/kcj.2012.42.5.345

Abstract

Deep vein thrombosis (DVT) is a common condition that is often under-diagnosed. Acquired or hereditary defects of coagulation or a combination of these defects may facilitate the development of DVT. Recurrent DVT, a positive family history or unusual presentation may warrant investigation for hereditary thrombophilia. Investigations are best when conducted at least one month after completion of a course of anticoagulant therapy. Most patients are managed with heparin in the acute stage overlapped by warfarin. The case presented here describes a 40-year old man undergoing three episodes of DVT. Investigations revealed protein C and protein S deficiency. Protein C, protein S and antithrombin deficiency either singly or in combination, are relatively common causes of hereditary thrombophilia. The case presented here serves as a reminder of the need to look into the underlying cause of venous thromboembolism.

Keyword

Deep vein thrombosis; Thrombophilia

MeSH Terms

Heparin
Humans
Protein C
Protein S
Protein S Deficiency
Thrombophilia
Venous Thromboembolism
Venous Thrombosis
Warfarin
Heparin
Protein C
Protein S
Warfarin