Kidney Res Clin Pract.  2014 Sep;33(3):161-164. 10.1016/j.krcp.2014.07.001.

Nephrotic syndrome complicated with portal, splenic, and superior mesenteric vein thrombosis

• Park BS
• Park S
• Jin K
• Choi G
• Park KM
• Jo KM
• Kim YW

• KMID: 2028693
• DOI: http://doi.org/10.1016/j.krcp.2014.07.001

Abstract

Thromboembolism is a major complication of nephrotic syndrome. Renal vein thrombosis and deep vein thrombosis are relatively common, especially in membranous nephropathy. However, the incidence of portal vein and superior mesenteric vein (SMV) thrombosis in patients with nephrotic syndrome is very rare. To date, several cases of portal vein thrombosis treated by anticoagulation therapy, not by thrombolytic therapy, have been reported as a complication of nephrotic syndrome. Here, we report a case of portal, splenic, and SMV thrombosis in a patient with a relapsed steroid dependent minimal change disease who was treated successfully with anticoagulation and thrombolytic therapy using urokinase. Radiologic findings and his clinical conditions gradually improved. Six months later, a complete remission of the nephrotic syndrome was observed and the follow-up computed tomography scan showed the disappearance of all portal vein, splenic vein, and SMV thrombi.

Keyword

Complications; Nephrotic syndrome; Thrombolytic therapy; Venous thrombosis

MeSH Terms

Follow-Up Studies
Glomerulonephritis, Membranous
Humans
Incidence
Mesenteric Veins*
Nephrosis, Lipoid
Nephrotic Syndrome*
Portal Vein
Renal Veins
Splenic Vein
Thromboembolism
Thrombolytic Therapy
Thrombosis*
Urokinase-Type Plasminogen Activator
Venous Thrombosis
Urokinase-Type Plasminogen Activator