Kidney Res Clin Pract.  2014 Sep;33(3):139-143. 10.1016/j.krcp.2014.07.004.

Clinicopathological role of kidney injury molecule-1 in immunoglobulin A nephropathy

• Lee YH
• Kim YG
• Lee SH
• Moon JY
• Jeong KH
• Lee TW
• Ihm CG

• KMID: 2028688
• DOI: http://doi.org/10.1016/j.krcp.2014.07.004

Abstract

BACKGROUND
Urinary kidney injury molecule-1 (KIM-1) is an early and sensitive biomarker of acute kidney injury, but it is unclear if it is a biomarker of chronic glomerulonephritis. We evaluated whether urinary KIM-1 levels in patients with immunoglobulin A (IgA) nephropathy can be a marker to reflect clinicopathological severity and predict the prognosis.
METHODS
We measured urinary KIM-1 levels in 40 patients (15 males; mean age 36.67+/-12.9 years) with IgA nephropathy and 10 healthy people (5 males; mean age 37.37+/-9.6 years) as controls. The correlation of urinary KIM-1 levels with patients' clinical parameters, histological grades, and follow-up data were analyzed using the modified H. S. Lee grading system and tubulointerstitial change scores.
RESULTS
Urinary KIM-1 levels were higher in patients with IgA nephropathy than healthy controls (P=0.001). Univariate and multivariate regression analyses showed that urinary KIM-1 levels had a direct correlation with H. S. Lee grade and tubulointerstitial inflammation (P=0.004 and P=0.011, respectively).
CONCLUSION
In patients with IgA nephropathy, urinary KIM-1 has a significant correlation with histopathologic severity.

Keyword

IgA nephropathy; Kidney biomarkers; Kidney injurymolecule-1(KIM-1)

MeSH Terms

Acute Kidney Injury
Follow-Up Studies
Glomerulonephritis
Glomerulonephritis, IGA*
Humans
Immunoglobulin A
Inflammation
Kidney*
Male
Prognosis
Immunoglobulin A