Korean J Obstet Gynecol.  1998 Nov;41(11):2739-2742.

Fetal Nuchal Translucency Measurement for Detection of Chromosomal Abnormalities in the First Trimester of High Risk Pregnancy

Abstract


OBJECTIVE
To determine the value of sonographic nuchal translucency measurement for the detection of chromosomal abnormalities in high risk pregnancies. METHOD: The feasibility of nuchal translucency was tested in a prospective study of 1260 pregnancies at 10- 13 weeks' gestation.
RESULTS
The nuchal translucency of 3 mm or greater was identified in 41 fetuses (3.2%), 19 of whom proved subsequently by either amniocentesis or postnatal follow-up have chromosomal abnormalities. The sensitivity of nuchal translucency for chromosomal abnormalities was 82.6% (19 of 23 cases), the positive predictive value of nuchal translucency for chromosomal abnormalities detection was 46.3% (19 of 41 cases).
CONCLUSION
The observed sensitivity, false-positive rate and predictive value suggest that sonographic nuchal translucency should be undertaken at 10 to 13 weeks of gestation.

Keyword

Nuchal translucency; Chromosomal abnormalities; Ultrasound screening

MeSH Terms

Amniocentesis
Chromosome Aberrations*
Female
Fetus
Follow-Up Studies
Humans
Nuchal Translucency Measurement*
Pregnancy
Pregnancy Trimester, First*
Pregnancy, High-Risk*
Prospective Studies
Ultrasonography
Full Text Links
  • KJOG
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error