J Korean Ophthalmol Soc.  1996 Jun;37(6):1054-1061.

Analysis of Inheritance in Infantile Nystagmus

• Kim IS
• Park SC

Abstract

Infantile nystagmus is characterized by involuntary oscillations of one or both eyes being present at birth or shortly thereafter without systemic or ophthalmologic lesions. Its inheritance pattern is not known exactly, but three types have been distinguished; irregular dominant, sex linked recessive, and simple recessive patterns. We observed 15 patients with family history and analyzed the characteristics of their inheritance patterns. We concluded the patterns of inheritance are irregular X-linked or autosomal dominant inheritance with incomplete penetrance in 7 families(47%), X-linked recessive or autosomal dominant inheritance in 5 families(33%), and autosomal dominant inheritance in 3 families(20%), respectively.

Keyword

Autosomal dominant; Infantile nystagmus; Inheritance pattern; Irregular dominant; X-linked recessive

MeSH Terms

Humans
Inheritance Patterns
Parturition
Penetrance
Wills*