Korean J Obstet Gynecol.  2006 Mar;49(3):572-579.

Prognostic factors of cervical cancer stage IB2 treated surgically

Affiliations
  • 1Department of Obstetrics and Gynecology, Gachon Medical School, Gil Hospital, Incheon, Korea. kgo02@hanmail.net

Abstract


OBJECTIVE
This study was performed to identify pathologic and clinical risk factors that predicted survival in cervical cancer stage IB2 patients treated surgically.
METHODS
The records of 52 patients with cervical cancer IB2 who underwent radical hysterectomy with pelvic lymph node dissection from 1997 to 2003 were reviewed retrospectively. Clinical and pathologic variables included age, tumor size (TS), histologic type, involvement of resection margin, parametrium invasion, lymph node metastasis (LN), lymph-vascular space invasion, depth of invasion, treatment modality and adjuvant radiation therapy (RTx). Survival analyses were performed by the Kaplan-Meier curves and the log-rank test. Independent prognostic factors were determined by Cox's proportional hazards model.
RESULTS
In the present study, median follow up was 46.5 months. With regard to the 2-year disease free survival rate and the 5-year survival rate, univariate analysis revealed no significant differences in subgroups according to age, histologic type, resection margin, parametrium, lymph-vascular space invasion, depth of invasion and treatment modality. Tumor size (p=0.0024), lymph node metastasis (p=0.0007) and radiation therapy (p=0.0398) significantly affected the 2-year disease free survival rate in univariate analysis. They (TS: p=0.0001, LN: p=0.0023, RTx: p=0.0428) also significantly affected 5-year survival rate in univariate analysis. Tumor size (RR 35.87, CI 2.94-438.26, p=0.01) and lymph node metastasis (RR 16.6, CI 1.36-202.05, p=0.03) affected 5-year survival rate in multivariate analysis.
CONCLUSION
In patients with cervical cancer stage IB2 who underwent operation regardless adjuvant radiation therapy, the important independent prognostic factors were tumor size and LN metastasis.

Keyword

Cervical cancer; Stage IB2; Survival; Prognostic factors

MeSH Terms

Disease-Free Survival
Follow-Up Studies
Humans
Hysterectomy
Lymph Node Excision
Lymph Nodes
Multivariate Analysis
Neoplasm Metastasis
Proportional Hazards Models
Retrospective Studies
Risk Factors
Survival Rate
Uterine Cervical Neoplasms*
Full Text Links
  • KJOG
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr