The analysis of prognostic factors in patients with epithelial ovarian cancer

Yun, Jung Hye; Lee, Hyun Young; Park, Hye Won; Shin, Jin Woo; Lee, Joung Min; Park, Chan Yong

Abstract

OBJECTIVE
To determine pathologic variables associated with overall survival and disease free survival of patients with epithelial ovarian cancer.
METHODS
Diesease free survival and overall survival of 80 ovarian cancer patients treated with primary surgery between January 1997 and December 2003 at our center were compared about various histopathologic variables. Survival analyses were performed by the Kaplan-Meier curves and the log-rank test. Independent prognostic factors were determined by Cox's proportional hazards model.
RESULTS
With regard to disease free survival, univariate analysis revealed no significant differences in subgroups according to age category, histologic type and grade. However, significant differences in disease free survival were found in stage category and residual tumor volume. Among these significant subgroups, the Cox-proportional hazards model showed that residual tumor volume was the only independent prognostic factor. There were significant differences in the overall survival of patients in subgroups according to stage categoty and residual tumor volume. Multivariate analysis revealed that residual tumor volume was the only independent significant adverse prognostic factor.
CONCLUSION
Our results showed that only residual tumor volume was the independent prognostic factor of disease free survival and overall survival in epithelial ovarian cancer patients.