Studies on Restoration of Functional and Morphological Damage of the Kidney Induced by Ureteral Ligation: I. Observation of Angiographic Changes of Experimental Hydronephrosis

Kim, Young Kyoon

Abstract

Experimental hydronephrosis in rabbit induced by ureteral ligation a been studied on its development and recovery angiographically. Intrarenal arteries were perfused with 7.5% barium sulfate under pressure from 60mm. to 180mm. Hg over a period of 15-20 minutes after various periods of uretera1 ligation or after release of obstruction and angiographic results were as follows: l. Ligation of ureter for 3 to 7 days maintains almost normal intrarenal vascular architecture though the size of the kidney increases. Deligation restores completely normal vascularity within one Week. 2. Ligation for 1l to 2l days causes irregular pattern of vascular distribution. Restoration begins at one week, significant restoration occurs at two weeks but no complete recovery at three weeks. 3. Ligation for 30 to 60 days looses intrarenal vascular architecture. Restoration seems to begin at two weeks. No complete recovery is observed at three weeks. 4. Size of hydronephrosis and severity of intrarenal vascular changes do not correlate. 5. Intravenous pyelography and radioisotope renography are not very suitable to reveal detailed information on development and recovery process of hydronephrosis.