J Gynecol Oncol.  2010 Jun;21(2):125-128. 10.3802/jgo.2010.21.2.125.

Mullerian adenosarcoma (heterologous) of the cervix with sarcomatous overgrowth: a case report with review of literature

Affiliations
  • 1Department of Cytopathology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. duggal.rajan@gmail.com
  • 2Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

Mullerian adenosarcoma is a rare biphasic malignant neoplasm of the cervix characterized by an admixture of benign epithelial elements and a malignant sarcomatous stromal component, which may be either homologous or heterologous. An aggressive variant of adenosarcoma, mullerian adenosarcoma with sarcomatous overgrowth (MASO) is extremely rare, with only two such cases being reported in the English literature to date. In this report we present a case of MASO of uterine cervix with heterologous elements in a 15-year-old unmarried girl presenting with foul smelling menstrual bleeding and passage of fleshy masses. Because MASO with heterologous elements seems to appear at the earliest stages of reproductive lifespan in women, and have an uncertain malignant potential, gynecologists and pathologists should be aware and think about the possibility of this tumor.

Keyword

Mullerian adenosarcoma; Sarcomatous overgrowth; Heterologous; Uterine cervix

MeSH Terms

Adenosarcoma
Adolescent
Cervix Uteri
Female
Hemorrhage
Humans
Single Person
Smell

Figure

  • Fig. 1 Endocervical glands surrounded by a sarcomatous stroma that typically exhibits periglandular condensation and focally polypoidal projection into the glands.

  • Fig. 2 Higher power view of the malignant stroma, demonstrating a clear demarcation between the low grade and high grade stromal components.


Reference

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