J Korean Diabetes Assoc.
2002 Dec;26(6):509-519.
Clinical Characteristics of Post-transplantation Diabetes Mellitus associated with Tacrolimus Therapy after Kidney Transplantation
- Affiliations
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- 1Department of Internal Medicine, Seoul National University College of Medicine, Korea.
- 2Department of Surgery, Seoul National University College of Medicine, Korea.
- 3The Institute of Endocrinology, Nutrition and Metabolism, Seoul National University Medical Research Center, Korea.
- 4Department of Internal Medicine, Kangwon National University, College of Medicine, Korea.
Abstract
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BACKGROUND: Post-transplantion diabetes mellitus (PTDM) is a major metabolic complication of transplantation and shows a variable incidence among studies with different population or different definition. We examined the incidence and the risk factors of PTDM in the Korean patients with tacrolimus-based immunosuppression following kidney transplantation, and also investigated the change of insulin secretory capacity.
METHODS
Twenty-one patients using tacrolimus as primary immunosuppressant were recruited and tested with serial 75-g oral glucose tolerance test (OGTT) at 0, 1, 3, and 6 months after kidney transplantation.
RESULTS
According to the American Diabetes Association criteria, the incidence of PTDM was 57.1% (12 of 21). Baseline characteristics of PTDM group were old age (especially > 40 yr), high body mass index, high fasting glucose, high plasma insulin, and increased insulin resistance. The insulin secretory capacity in PTDM group was maximally suppressed 3 months after transplantation and was gradually restored thereafter along with dose reduction of tacrolimus.
CONCLUSIONS
Attention should be paid to the patients, especially who are over 40 yr of age, throughout the high dose tacrolimus therapy.
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