J Korean Diabetes Assoc.  2007 Mar;31(2):97-104. 10.4093/jkda.2007.31.2.97.

The Roles of Carbon Monoxide in Islets

• Lee HW
• Yoon JS

• KMID: 2008077
• DOI: http://doi.org/10.4093/jkda.2007.31.2.97

Abstract

No abstract available.

MeSH Terms

Carbon Monoxide*
Carbon*
Carbon
Carbon Monoxide

Figure

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  Fig. 1 Schematic of the heme oxygenase reaction.

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  Fig. 2 The interactions of NO and CO on activating guanylate cyclase pathway.

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  Fig. 3 Summary of the mechanism of CO's protection.

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  Fig. 4 A, Quantitative analysis of HO-1 protein & mRNA expression in freshly isolated murine islets cultured in the presence of FePP; B, FePP-induced HO-1 upregulation results in partial protection from cytokine and Fas-mediated apoptosis induction in βTC3 cells40).

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  Fig. 5 Time course of return to normoglycemia in mice that received a syngeneic marginal mass islet graft. A, time curve to normoglycemia of recipient mice that received FePP-treated islets (● vs control ○). MT to normoglycemia was 36 ± 28.9 days (P = ns); B, Time to normoglycemia of mice that received untreated islets and were treated in vivo with CoPP (□). MT was 33 ± 0.4 days (P = ns); C, Time to normoglycemia in mice that received FePP-treated islets and were treated in vivo with CoPP (■). MT was 18 ± 28.3 days (P = 0.006)40).

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  Fig. 6 Exposure of murine islet to CO improves islet survival/function after transplantation. *P = 0.001 vs. control46).

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