A Case of Metastatic Hepatocellular Harcinoma to the Skull

Kim, Min Cheol; Seo, Byung Chul; Oh, Deuk Young; Lee, Paik Kwon; Rhie, Jong Won; Ahn, Sang Tae

Abstract

PURPOSE: Hepatocellular carcinoma is a highly malignant disorder that carries a poor prognosis. It is a fatal disease with a high incidence, especially in areas with an already high prevalence of hepatitis types B & C. The primary sites for extrahepatic metastases include the lung and adrenal glands, while bone, especially the skull, is rarely affected. This paper notes a rare case of extrahepatic metastasis to the skull.
METHODS
A 62-year-old male, with a previous history of hepatitis B, developed hepatocellular carcinoma. The patient received several treatments of TACE(Transarterial chemoembolization) and PEI(Percutaneous ethanol injection) with no resolution, which prompted a hepatology follow-up. Recently, patient requested to have an enlarging mass on the forehead removed, for which an incisional biopsy was perfomed since the mass involved bone. Pathologic findings confirmed metastatic HCC.
RESULTS
The only complication encountered during the incisional biopsy was profuse bleeding from the incision site. There was some difficulty in controlling the bleeding, but hemostasis was achieved using Gelfoam. There were no postoperative complications. The patient was treated with radiotherapy and follow-up
CONCLUSION
Patients with cranial metastasis of HCC presents with a subcutaneous mass and a headache while simple X-rays show osteolytic lesions, computed tomography studies are needed for a definitive diagnosis. Treatement options include radiotherapy, surgery and chemotherapy. In this case the patient received radiotherapy. Skull metastases should be considered in the differential diagnosis of patients who present with a subcutaneous mass and an osteolytic defect on X-ray films of the skull.