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PURPOSE We analysed the clinical data to compare the usefulness of ultrasound guided vacuum-assisted Mammotome biopsy between 8G and 11G probes. METHODS: 108 cases in this study underwent an ultrasound- guided minimally invasive excisional breast biopsy through small incision. Removal of the breast lesions was accomplished Mammotome biopsy with 8G or 11G probes. RESULTS: The 108 lesions was excised. Mean size of the lesions were 10.7 mm in 8G and 9 mm in 11G. 105 lesions (95%) had benign pathology, three lesions (2.8%) were malignant, and two lesions (1.9%) had atypical ductal hyperplasia. As procedural complications, hematoma was 23/58 (39.7%) in 8G and 10/50 (20%) in 11G, and ecchymosis was 33/58 (55%) in 8G and 11/50 (22%) in 11G. But there was no major complications which need hospitalization and surgical intervention. CONCLUSION: Breast biopsy using Mammotome with 8G probe is as safe as 11G and effective technique.