J Korean Breast Cancer Soc.  2003 Sep;6(3):180-185. 10.4048/jkbcs.2003.6.3.180.

The Efficacy of Sentinel Node Biopsy Using Subareolar Injection of Radioactive Material in Breast Cancer

Affiliations
  • 1Department of Surgery, College of Medicine, Ewha Womans University, Seoul, Korea. mbit@ewha.ac.kr
  • 2Department of Pathology, College of Medicine, Ewha Womans University, Seoul, Korea.
  • 3Department of Radiology, College of Medicine, Ewha Womans University, Seoul, Korea.
  • 4Department of Radiation Oncology, College of Medicine, Ewha Womans University, Seoul, Korea.

Abstract

PURPOSE
This study was designed to evaluate the feasibility of sentinel node biopsy (SNB) using subareolar injection of radioactive material in breast cancer. METHODS: The prospective study was performed of 112 breast cancers (T1 or T2 stages) at Ewha Womans University Mok-Dong Hospital from February 2001 to June 2003. Patients underwent lymphoscintigraphy using 99mTc sulfur colloid. The feasibility of SNB was assessed through comparison with simultaneous axillary node dissection. RESULTS: All patients were women, and the median age was 46 years. Internal mammary sentinel lymph node was identified in 2 cases (1.8%). The first node was appeared on lymphoscintigraphy around at 10.7 minutes after subareolar injection. Sentinel nodes could be identified in 111 (99.1%) among 112 patients with a gamma probe. The mean number of harvested sentinel nodes were 3.3 and metastasis was noted 80 of 368 nodes (21.7%). False negative rate was 4.1%. CONCLUSION: SNB using subareolar injection of radioactive material could be a alternative method to replace axillary node dissection in T1 or T2 breast cancers, especially in case of clinical node negative patients.

Keyword

Sentinel node; Subareolar injection; Lymphoscintigraphy

MeSH Terms

Biopsy*
Breast Neoplasms*
Breast*
Colloids
Female
Humans
Lymph Nodes
Lymphoscintigraphy
Neoplasm Metastasis
Prospective Studies
Sulfur
Colloids
Sulfur

Cited by  1 articles

Utility of Breast Sentinel Lymph Node Biopsy Using the Day-Before or the Same-Day Subareolar Injection of 99mTc-Tin Colloid
Kang Seok Kim, Yang Hee Kim, Nam Sun Paik, Min Suk Kim, Chang Woon Choi, Nan Mo Moon, Woo Chu Noh
J Breast Cancer. 2006;9(2):121-126.    doi: 10.4048/jbc.2006.9.2.121.

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