J Korean Assoc Oral Maxillofac Surg.  2007 Oct;33(5):437-444.

High dose exposures of vinyl acetate induce neoplastic transformation of human epithelial cells in culture

• Cho JH
• Kim CS

Abstract

Vinyl acetate has been widely used for the manufacture of polyvinyl alcohol emulsion, which is primary ingredient of adhesive, paints, textile, paperboard coatings, etc. Since these products are plentiful and frequently used around us, workers and consumers are at health risk. International Agency for Research on Cancer (IARC) classified vinyl acetate as group 2B (possibly carcinogenic to humans). Among the organs targeted, the oral cavity is the most vulnerable organ affected by the carcinogenic effects of vinyl acetate. Since the origin of most of oral cancer is derived from the epithelial cells, it is important to understand the carcinogenic potential of vinyl acetate in human epithelial cells. Thus, the present study has attempted to utilize the immortalized human epithelial cell model to assess the carcinogenic potency of this chemical and to understand the underlying mechanisms.

Keyword

Vinyl acetate; Neoplastic transformation; Human epithelial cell

MeSH Terms

Adhesives
Epithelial Cells*
Humans*
International Agencies
Mouth
Mouth Neoplasms
Paint
Polyvinyl Alcohol
Textiles
Adhesives
Polyvinyl Alcohol