Korean J Stroke.  2011 Dec;13(3):107-113. 10.5853/kjs.2011.13.3.107.

Rat Models for Ischemic Stroke

• Kim HY
• Koh SH
• Kim SH

• KMID: 1996980
• DOI: http://doi.org/10.5853/kjs.2011.13.3.107

Abstract

Highly reproducible and consistent ischemic stroke models are critical for obtaining more confident data. To date, the infarct variation of several ischemic rat models is considerable. Therefore, many factors related to outcome variation and infarct growth must be controlled. Among various infarct models of rodents, intraluminal filament model is common by virtue of its consistency of the success rate and the outcomes. Recently more long-term evaluation of functional and imaging outcomes is considered in terms of clinical practice. Concise and subsequent outcome assessment could result in the improvement of translational stroke research. We recommend that the researchers should remember the guidelines addressed by the Stroke Therapy Academic Industry Roundtable (STAIR) and the Good Laboratory Practice (GLP).

Keyword

Ischemic stroke model; Research; Guideline

MeSH Terms

Animals
Rats
Rodentia
Stroke
Virtues