Obstet Gynecol Sci.  2015 Jan;58(1):32-39. 10.5468/ogs.2015.58.1.32.

Krukenberg tumors of gastric origin versus colorectal origin

• Jeung YJ
• Ok HJ
• Kim WG
• Kim SH
• Lee TH

• KMID: 1994224
• DOI: http://doi.org/10.5468/ogs.2015.58.1.32

Abstract

OBJECTIVE
The aim of this study is to compare the each clinical manifestation related with its mean survival time of Krukenberg tumors (KTs) of gastric origin versus with that of colorectal origin.
METHODS
A total of 156 consecutive patients diagnosed with KTs of the ovary who underwent surgical treatment at a single institution between 2001 and 2010 were retrospectively evaluated. Each clinical manifestation related with its mean survival time compared two different groups. Survival analyses and comparisons were performed using the Kaplan-Meier method.
RESULTS
Among the 156 patients with KT, 111 patients with KTs of gastric origin and 45 patients with KTs of colorectal origin were identified. For all patients with KTs, median survival time was 22.7 months. Each mean survival time among all patients with KTs of gastric origin and colorectal origin was 19.2 months and 27.3 months. The results showed that mean survival time of postmenopausal patients was 19.0 months compared with 32.5 months for premenopausal patients (P=0.015). Among all patients, mean survival time of those with metachronous cancer was longer than those with synchronous cancer (P=0.001). In all cases, especially when only one ovary was invaded, the mean survival time was relatively higher (P=0.001).
CONCLUSION
Patients with KTs of colorectal origin had a better prognosis than those of gastric origin. In all cases of KT, the mean survival time was significantly longer in postmenoposal patients, metachronous disease and unilateral ovarian involvement. Notably, synchronous, ascites positive, and ovary only metastasis showed more longer mean survival time in the KTs of colorectal origin than KTs of gastric origin.

Keyword

Krukenberg tumor; Metastatic ovarian cancer; Survival rate

MeSH Terms

Ascites
Female
Humans
Krukenberg Tumor*
Neoplasm Metastasis
Ovary
Prognosis
Retrospective Studies
Survival Rate

Figure

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  Fig. 1 Kaplan-Meier survival curve. (A) Overall survival in all patients (n=156). (B) Comparing overall survival gastric origin Krukenberg tumor to colorectal origin Krukenberg tumor.

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  Fig. 2 Kaplan-Meier survival curve. (A) Comparing overall survival premenopause patients to postmenopause patients. (B) Comparing overall survival synchronous Krukenberg tumor to metachronous Krukenberg tumor.

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  Fig. 3 Kaplan-Meier survival curve. (A) In synchronous Krukenberg tumor (KT) patients, comparing overall survival gastric origin KT to colorectal origin KT. (B) In all patients with ascites, comparing overall survival gastric origin to colorectal origin.

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  Fig. 4 Kaplan-Meier survival curve. (A) Comparing overall survival unilateral ovary invasion patients to bilateral ovary invasion patients. (B) Comparing overall survival only ovary metastasis patients to extraovary metastasis patients.

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