Korean Lepr Bull.
2004 Jul;37(1):3-14.
Comparison of rpoT gene of M. leprae strain from korean and foreign leprosy patients
- Affiliations
-
- 1Institute of Hansen's Disease, The Catholic University of Korea, Seoul 137-701 Korea. guetae@catholic.ac.kr
- 2Department of Pathology, The Catholic University of Korea, Seoul 137-701 Korea.
- 3The Jesus Hospital, Leprosy Mission, Taegu City 704-080 Korea.
- 4Leprosy Research Center, National Institute of Infectious Disease, Tokyo, 189-0002 Japan.
Abstract
- The variance of tandem repeats in the rpoT gene of Mycobacterium leprae was recently demonstrated. The objects of this study was to examine the proportion and distributions of the genotypes of M. leprae in Korea and to compared it with genotypes of M. leprae form foreign leprosy patients using difference of the tandem repeats. Among 101 cases, 72 isolated from Korea and 4 cases from Japan (except Okinawa) demonstrated four copies of the 6 bp tandem repeats in the rpoT gene, and three copies were found in isolates from two korean, 2 cases of Okinawa in Japan, and those from Southeast Asian countries, Peru and Paraguay. These results reveal the genetic diversity of M. leprae and the related genotype-specific distribution in the world. In this study, a more detailed explanation can be also possible regarding the transmission route of M. leprae.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- M. leprae typing by genomic diversity of clinical isolates in Korea
- The Study of Epidemiological investigation of Leprosy by Using Polymerase Chain Reaction
- The Review of Epidemiological investigation of Leprosy by Using Polymerase Chain Reaction
- The application of TD (Touch-Down) PCR in Diagnosis of leprosy and Detection of MDT-resistant M. leprae
- The role of mycobacterial katG gene in activation of isoniazid
