Korean J Urol.  2007 Jul;48(7):754-756. 10.4111/kju.2007.48.7.754.

Nested Variant of Transitional Cell Carcinoma with Hydronephrosis

• Jang WS
• Kwon MS
• Park SY
• Cho JS

• KMID: 1990231
• DOI: http://doi.org/10.4111/kju.2007.48.7.754

Abstract

The nested variant of transitional cell carcinoma(TCC) is rarely found in the bladder. Only about 80 such cases have been reported in the literature. Irregular nests and tubules of TCC infiltrating the lamina propria, with no involvement of the mucosal layer, characterize this disease. These characteristics make it difficult to diagnose the nested variant of transitional cell carcinoma. In this study we reported on a new case and review the relevant literature. This case was accompanied with hydronephrosis. We report on this case with its accompanying hydronephrosis because of its rarity and unusual histology, and also its prognostic significance emphasizes the need to distinguish it from classic TCC.

Keyword

Bladder; Transitional cell carcinoma; Nested; Variant

MeSH Terms

Carcinoma, Transitional Cell*
Hydronephrosis*
Mucous Membrane
Urinary Bladder

Figure

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  Fig. 1. Contrast-enhanced CT scan of the abdomen showed the right hydronephrosis, delayed nephrogram, perinephric infiltration (A) and focally enhancing wall thickening at the right posterolateral bladder wall, and this involved the right ureterovasical junction (UVJ) portion (B).

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  Fig. 2. Nested variant of the transitional cell bladder carcinoma. The tumor is growing as uniform round nests.

Reference

References

1. Murphy WM, Grignon DJ, Perlman EJ. Tumors of the kidney, bladder and related urinary structures. Murphy WM, Grignon DJ, Perlman EJ, editors. editors.Atrals of tumor pathology. 4th ed.Washington DC: American Registry of Pathology;2004. p. 283–7.

2. Dundar E, Acikalin MF, Can C. The nested variant of urothelial carcinoma: an aggressive tumor closely simulating benign lesions. Pathol Oncol Res. 2006; 12:105–7.

3. Talbert ML, Young RH. Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases. Am J Surg Pathol. 1989; 13:374–81.

4. Paik SS, Park MH. The nested variant of transitional cell carcinoma of the urinary bladder. Br J Urol. 1996; 78:793–4.

5. Ozdemir BH, Ozdemir G, Sertcelik A. The nested variant of the transitional cell bladder carcinoma: a case report and review of the literature. Int Urol Nephrol. 2000; 32:257–8.

6. Murphy WM, Deana DG. The nested variant of transitional cell carcinoma: a neoplasm resembling proliferation of Brunn's nests. Mod Pathol. 1992; 5:240–3.

7. Lin O, Cardillo M, Dalbagni G, Linkov I, Hutchinson B, Reuter VE. Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases. Mod Pathol. 2003; 16:1289–98.

8. Ooi SM, Vivian J, Sinniah R, Troon S. Nested variant of urothelial carcinoma: a rare presentation. Urology. 2006; 67:845.

9. Holmang S, Johansson SL. The nested variant of transitional cell carcinoma: a rare neoplasm with poor prognosis. Scand J Urol Nephrol. 2001; 35:102–5.