Korean J Urol.  2007 Dec;48(12):1251-1257. 10.4111/kju.2007.48.12.1251.

Influence of 0.2mg Tamsulosin Treatment on the Erectile and Ejaculatory Functions in Patients with Benign Prostatic Hyperplasia

• Song SH
• Son H
• Paick JS

• KMID: 1990149
• DOI: http://doi.org/10.4111/kju.2007.48.12.1251

Abstract

PURPOSE: The aim of this study was to evaluate the influence of 8 weeks of 0.2mg tamsulosin medication on the erectile and ejaculatory functions of patients with benign prostatic hyperplasia(BPH).
MATERIALS AND METHODS
108 patients with BPH and they were without prostate cancer and neurogenic bladder were included in this study. Initial evaluations included a thorough history, digital rectal exam, urinalysis, serum prostate-specific antigen, uroflowmetry(UFM), post void residual urine measurement, transrectal ultrasound, International Prostatic Symptom Score(IPSS) and an International Index of Erectile Function(IIEF) and ejaculatory function questionnaire. After 4 and 8 weeks of medication, we analyzed the differences of these parameters at each week.
RESULTS
The mean age of the patients was 61.3+/-9.0 years old and their prostate volume was 35.7+/-21.3ml. The IIEF erectile function(EF) domain score showed no statistically significant difference after medication. However, the orgasmic function domain score showed a significant decrease from 16.3+/-9.3 to 15.7+/-9.6 at the 4th and 8th week. Regarding the ejaculatory function, when the patients were divided into two groups according to the EF domain score(<10, > or =11), the score of the ejaculatory volume showed a tendency to decrease from 2.5+/-1.0 to 2.2+/-1.2(p=0.07), and the score for satisfaction about ejaculation was decreased from 3.0+/-1.2 to 2.5+/-1.5(p=0.01) in the larger EF domain group after 8 weeks of treatment. The IPSS score and UFM parameters improved significantly after medication(p<0.05).
CONCLUSIONS
For the patients with BPH, 8 weeks of 0.2mg tamsulosin medication caused significant improvement in their voiding function. In addition, our findings suggest that 0.2mg tamsulosin medication may the influence erectile and ejaculatory function.

Keyword

Tamsulosin; Benign prostatic hyperplasia; Erectile function; Ejaculation

MeSH Terms

Ejaculation
Humans
Male
Orgasm
Prostate
Prostate-Specific Antigen
Prostatic Hyperplasia*
Prostatic Neoplasms
Questionnaires
Ultrasonography
Urinalysis
Urinary Bladder, Neurogenic
Prostate-Specific Antigen

Figure

• 

  Fig. 1 Ejaculatory function score in 78 patients with an erectile function (EF) domain score more than 11. Q No. 1, ejaculatory function question number 1; Q No. 4, ejaculatory function question number 4; 4 weeks, 4 weeks after tamsulosin 0.2mg medication; 8 weeks, 8 weeks after tamsulosin 0.2mg medication, Values are shown as means. *p<0.05 compared with the baseline by a paired sample t-test.

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