Korean J Nephrol.  1998 Nov;17(6):978-982.

A Case of Membranous Nephropathy Improved by Removal of Early Gastric Cancer

• Woo CK
• Suh KH
• Shin KS
• Lee DH
• Lee DY
• Je SJ
• Hwang JH
• Lee CK
• Kim IS
• Kim YJ

Abstract

The nephrotic syndrome in association with extrarenal malignancy is not an uncommon event. The membranous nephropathy is most frequently associated with various carcinomas of the lung, breast, stomach and colon. Though the exact causal relationship has not been determined completely, deposition of the immune complexes composed of antitumor antibody and tumor antigens in the subepithelium is most favorably accepted. We experienced a patient with previously diagnosed membranous nephropathy and subsequently demonstrated early gastric cancer during patient follow-up. After surgical resection proteinuria improved significantly. All physicians are strongly recommended to examine thoroughly and search carefully for possibility of concomitant occult malignancy when an aged patient, especially over 40 years old, is diagnosed as a nephrotic syndrome.

Keyword

Membranous nephropathy; Early gastric cancer; Proteinuria; Immune complex

MeSH Terms

Adult
Antigen-Antibody Complex
Antigens, Neoplasm
Breast
Colon
Follow-Up Studies
Glomerulonephritis, Membranous*
Humans
Lung
Nephrotic Syndrome
Proteinuria
Stomach
Stomach Neoplasms*
Antigen-Antibody Complex
Antigens, Neoplasm