Korean J Nephrol.  2000 Nov;19(6):1150-1153.

A Case of Pendipronil(R) Poisoning Treated by Hemoperfusion and Methylene Blue

• Jung BK
• Kim JK
• Pak YK
• Park SH
• Kim KW

Abstract

Pendipronil(R) overdose is uncommon in Korea. Pendipronil(R) is a selective herbicide used to control most annual grasses and certain broadleaf weeds in field corn, potatoes, rice, etc. and is the substance including pendimethalin and propanil. Pendimethalin is slightly to practically nontoxic by ingestion but may be mildly to moderately irritating to the linings of the mouth, nose, throat, and lungs. Propanil toxicity is evidenced by varying clinical pictures ranging from deep cyanosis in an otherwise alert normal appearing individual to restlessness, dyspnea, extensive hemolytic anemia, methemoglobinemia, sulfhemoglobinemia and serious central nervous system dysfunction. For the treatment of methemoglobinemia, gastric lavage, activated charcoal, methylene blue and exchange transfusion should be used. We experienced a case of acute massive Pendipronil(R) intoxication in 31 years old woman due to voluntary ingestion of 48g of this drug as a suicide attempt. A moderate methemoglobinemia developed, accompanied by drowsy mental status, nausea, vomiting, headache, intensive cyanosis. The patient recovered completely after intravenous methylene blue injection and cellulose coated hemoperfusion charcoal (Adsorba 300C(R)) and conservative treatment.

Keyword

Pendipronil; Methylene blue; Methemoglobinemia; Hemoperfusion

MeSH Terms

Adult
Anemia, Hemolytic
Cellulose
Central Nervous System
Charcoal
Cyanosis
Dyspnea
Eating
Female
Gastric Lavage
Headache
Hemoperfusion*
Humans
Korea
Lung
Methemoglobinemia
Methylene Blue*
Mouth
Nausea
Nose
Pharynx
Poaceae
Poisoning*
Propanil
Psychomotor Agitation
Solanum tuberosum
Suicide
Sulfhemoglobinemia
Vomiting
Zea mays
Cellulose
Charcoal
Methylene Blue
Propanil