Korean J Reprod Med.  2009 Mar;36(1):55-61.

Clinical Outcome of IVF-ET using Testicular Sperm Retrieved from Patients with Obstructive Azoospermia or Hypospermatogenesis

• Han SC
• Park YS
• Choi SJ
• Lee SH
• Hong SB
• Lee HS
• Lim CK
• Song IO
• Seo JT

Abstract

OBJECTIVE
To compare the clinical outcomes of ICSI with sperm retrieved from testicular tissue in patients with obstructive azoospermia (OA) or hypospermatogenesis (HS).
METHODS
From January 2003 through December 2006, 155 patients with OA (241 cycles) and 28 patients with HS (34 cycles) were included in this study. We compared clinical outcomes of ICSI with testicular sperm such as fertilization rate, implantation rate, clinical pregnancy rate and delivery rate. Data were statistically analyzed using t-test and chi-square -test.
RESULTS
Testicular spermatozoa could not be retrieved in 1 out of the 21 cycles where fresh testicular sperm extraction in HS patients. Fertilization rate (FR) was significantly higher in OA than HS (75.6 % vs. 62.6%, p<0.001). Cleavage rate (CR) per fertilized zygote was also significantly higher in OA than that in HS (66.8% vs. 54.8% p<0.001). However, there were no significant differences in good embryo rate (GER), clinical pregnancy rate (CPR), implantation rate (IR) and delivery rate (DR).
CONCLUSION
Our results show that testicular sperm of HS does not affect CPR, IR, and DR although it has shown reduced FR and CR.

Keyword

Obstructive azoospermia; Hypospermatogenesis; Testicular spermatozoa; ICSI

MeSH Terms

Azoospermia
Cardiopulmonary Resuscitation
Embryonic Structures
Fertilization
Humans
Male
Oligospermia
Pregnancy Rate
Sperm Injections, Intracytoplasmic
Spermatozoa
Zygote