J Cardiovasc Ultrasound.  2011 Sep;19(3):134-139. 10.4250/jcu.2011.19.3.134.

Subclinical Myocardial Dysfunction in Metabolic Syndrome Patients without Hypertension

• Seo JM
• Park TH
• Lee DY
• Cho YR
• Baek HK
• Park JS
• Kim MH
• Kim YD
• Choi SY
• Lee SM
• Hong YS

• KMID: 1980367
• DOI: http://doi.org/10.4250/jcu.2011.19.3.134

Abstract

BACKGROUND
The aim of this study was to evaluate myocardial function in patients with non-hypertensive metabolic syndrome.
METHODS
We selected metabolic syndrome patients (n = 42) without evidence of hypertension and compared them to age-matched control individuals (n = 20). All patients were evaluated by two-dimensional and tissue Doppler echocardiography including tissue Doppler derived strain and strain rate measurements.
RESULTS
There were no significant differences between the two groups in mitral E and A inflow velocities or the E/A ratio. However, systolic and early diastolic myocardial velocities, and strain rate were significantly lower in patients with metabolic syndrome than in the control group (all p < 0.05). Multiple stepwise regression analyses revealed that age, waist circumference, and systolic blood pressure were independently associated with peak systolic myocardial velocity.
CONCLUSION
These results indicate that metabolic syndrome patients without hypertension may have decrease of myocardial systolic and early diastolic velocities on tissue Doppler imaging, even if they appear to have normal systolic and diastolic function on conventional echocardiography.

Keyword

Metabolic syndrome; Doppler echocardiography

MeSH Terms

Blood Pressure
Echocardiography
Echocardiography, Doppler
Humans
Hypertension
Sprains and Strains
Waist Circumference

Figure

• 

  Fig. 1 Mean values of myocardial velocities and strain rate by tissue Doppler imaging in control and MS group. MS: metabolic syndrome, Sm: peak systolic, Em: early diastolic, Ssr: peak systolic, Esr: early diastolic.

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