Korean J Gynecol Oncol.  2005 Jun;16(2):123-132.

Correlation between SCC antigen and the prognosis of cervical cancer patients following concurrent chemoradiotherapy

• Park SH
• Kim YT
• Kim JW
• Kim JH
• Kim S
• Yoon BS
• Kim WS

Abstract

OBJECTIVE
The aim of this study was to determine the correlation between SCC Ag and the prognosis in cervical cancer patients following concurrent chemoradiotherapy (CCRT).
METHODS
The charts of 116 patients following concurrent chemoradiotherapy among 330 patients diagnosed to cervical cancer at Yonsei University Medical Center from Jan. 1998 to June 2003 were reviewed retrospectively. Clinical characteristics (age, parity, body mass index), stage, lesion size, cell type, squamous cell subtype, initial SCC Ag (<1.5 and >or=1.5), posttreatment SCC Ag (<1.5 and >or=1.5) was evaluated with overall survival. Distribution of SCC Ag level before CCRT in relation to FIGO stage and failure pattern in SCC positive patients before CCRT were reviewed. Overall survival was estimated according to respectively, subgroups of initial SCC Ag, SCC Ag after 2nd CCRT and posttreatment SCC Ag. Chi square test and Kaplan Meier test were used for statistical analysis (P<0.05).
RESULTS
Overall survival was significantly correlated with only stage (P=0.0014). Two patients (15.4%) among 13 patients with recurrence had SCC Ag<1.5. Subgroups (1.5CONCLUSION
The measurements of the levels of initial SCC Ag, SCC Ag after 2nd CCRT and posttreatment SCC Ag are expected to be useful in predicting the prognosis of the patients with cervical cancer.

Keyword

SCC antigen; Cervix cancer; Concurrent chemoradiotherapy; Prognosis

MeSH Terms

Academic Medical Centers
Cell Size
Chemoradiotherapy*
Female
Humans
Kaplan-Meier Estimate
Parity
Prognosis*
Recurrence
Retrospective Studies
Uterine Cervical Neoplasms*