Korean J Pain.  2013 Apr;26(2):181-185. 10.3344/kjp.2013.26.2.181.

Spondylodiscitis after Cervical Nucleoplasty without Any Abnormal Laboratory Findings

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. hiitsme@snubh.org

Abstract

Infective spondylodiscitis is a rare complication that can occur after interventional spinal procedures, of which symptoms are usually back pain and fever. Early diagnosis of infective spondylodiscitis is critical to start antibiotics and to improve prognosis. Laboratory examinations including complet blood cell count (CBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) are conventional tools for the early detection of infectious spondylitis. However, we experienced infective spondylodiscitis after cervical nucleoplasty which did not display any laboratory abnormalities, but was diagnosed through an MRI. A patient with cervical disc herniation received nucleoplasty at C5/6 and C6/7. One month later, the patient complained of aggravated pain. There were neither signs of chill nor fever, and the laboratory results appeared normal. However, the MRI findings were compatible with infectious spondylodiscitis at the nucleoplasty site. In conclusion, infectious spondylodiscitis can develop after cervical nucleoplasty without any laboratory abnormalities. Therefore, an MRI should be taken when there is a clinical suspicion for infection in order to not miss complications after interventional procedures, even if the laboratory findings are normal.

Keyword

complication; infection; magnetic resonance imaging; nucleoplasty; spondylodiscitis

MeSH Terms

Anti-Bacterial Agents
Back Pain
Blood Cell Count
Blood Sedimentation
C-Reactive Protein
Discitis
Early Diagnosis
Fever
Humans
Magnetic Resonance Imaging
Prognosis
Spondylitis
Anti-Bacterial Agents
C-Reactive Protein

Figure

  • Fig. 1 Nucleoplasty at the C5/6 disc. (A) Anterior-posterior view and (B) lateral view.

  • Fig. 2 MR image after 6 weeks. C6/7 spondylodischitis is identified. (A) T2 sagittal view and (B) T2 axial view.


Cited by  2 articles

Should We Start Treating Chronic Low Back Pain with Antibiotics Rather than with Pain Medications?
Christof Birkenmaier
Korean J Pain. 2013;26(4):327-335.    doi: 10.3344/kjp.2013.26.4.327.

Diagnosis and management of infections related to spinal pain interventions
Sang Cheol Yoon, Eun Joo Choi
Anesth Pain Med. 2024;19(4):294-301.    doi: 10.17085/apm.24140.


Reference

1. Di Martino A, Papapietro N, Lanotte A, Russo F, Vadalà G, Denaro V. Spondylodiscitis: standards of current treatment. Curr Med Res Opin. 2012; 28:689–699. PMID: 22435926.
Article
2. Jiménez-Mejías ME, de Dios Colmenero J, Sánchez-Lora FJ, Palomino-Nicás J, Reguera JM, García de la Heras J, et al. Postoperative spondylodiskitis: etiology, clinical findings, prognosis, and comparison with nonoperative pyogenic spondylodiskitis. Clin Infect Dis. 1999; 29:339–345. PMID: 10476739.
Article
3. Bonaldi G, Baruzzi F, Facchinetti A, Fachinetti P, Lunghi S. Plasma radio-frequency-based diskectomy for treatment of cervical herniated nucleus pulposus: feasibility, safety, and preliminary clinical results. AJNR Am J Neuroradiol. 2006; 27:2104–2111. PMID: 17110676.
4. Chen F, Lü G, Kang Y, Ma Z, Lu C, Wang B, et al. Mucormycosis spondylodiscitis after lumbar disc puncture. Eur Spine J. 2006; 15:370–376. PMID: 16328227.
Article
5. Lotfinia I, Vahedi P. Late-onset post-diskectomy tuberculosis at the same operated lumbar level: case report and review of literature. Eur Spine J. 2010; 19(Suppl 2):S226–S232. PMID: 20446000.
Article
6. Bavinzski G, Schoeggl A, Trattnig S, Standhardt H, Dietrich W, Reddy M, et al. Microsurgical management of postoperative disc space infection. Neurosurg Rev. 2003; 26:102–107. PMID: 12962295.
Article
7. Schulitz KP, Assheuer J. Discitis after procedures on the intervertebral disc. Spine. 1994; 19:1172–1177. PMID: 8059276.
Article
8. Mustard RA Jr, Bohnen JM, Haseeb S, Kasina R. C-reactive protein levels predict postoperative septic complications. Arch Surg. 1987; 122:69–73. PMID: 3800652.
Article
9. Sim SE, Ko ES, Kim DK, Kim HK, Kim YC, Shin HY. The results of cervical nucleoplasty in patients with cervical disc disorder: a retrospective clinical study of 22 patients. Korean J Pain. 2011; 24:36–43. PMID: 21390177.
Article
10. Ozuna RM, Delamarter RB. Pyogenic vertebral osteomyelitis and postsurgical disc space infections. Orthop Clin North Am. 1996; 27:87–94. PMID: 8539056.
Article
11. Rohde V, Meyer B, Schaller C, Hassler WE. Spondylodiscitis after lumbar discectomy. Incidence and a proposal for prophylaxis. Spine. 1998; 23:615–620. PMID: 9530794.
12. Meyer B, Schaller K, Rohde V, Hassler W. The C-reactive protein for detection of early infections after lumbar microdiscectomy. Acta Neurochir. 1995; 136:145–150. PMID: 8748845.
Article
13. Bircher MD, Tasker T, Crawshaw C, Mulholland RC. Discitis following lumbar surgery. Spine. 1988; 13:98–102. PMID: 3381147.
Article
14. Kwon SC, Kim SJ, Shin HS, Park SK. Erythrocyte sedimentation rate, C-reactive protein, and white blood cell count after lumbar discectomy. J Korean Neurosurg Soc. 1998; 27:1508–1511.
15. Citak M, Backhaus M, Kälicke T, Hilal Z, Muhr G, Frangen TM. Myths and facts of spondylodiscitis: an analysis of 183 cases. Acta Orthop Belg. 2011; 77:535–538. PMID: 21954765.
16. Gerometta A, Bittan F, Rodriguez Olaverri JC. Postoperative spondilodiscitis. Int Orthop. 2012; 36:433–438. PMID: 22307558.
Article
17. Zarghooni K, Röllinghoff M, Sobottke R, Eysel P. Treatment of spondylodiscitis. Int Orthop. 2012; 36:405–411. PMID: 22143315.
Article
18. Palestro CJ, Love C, Miller TT. Infection and musculoskeletal conditions: imaging of musculoskeletal infections. Best Pract Res Clin Rheumatol. 2006; 20:1197–1218. PMID: 17127204.
19. Khan IA, Vaccaro AR, Zlotolow DA. Management of vertebral diskitis and osteomyelitis. Orthopedics. 1999; 22:758–765. PMID: 10465488.
Article
20. Maiuri F, Iaconetta G, Gallicchio B, Manto A, Briganti F. Spondylodiscitis. Clinical and magnetic resonance diagnosis. Spine. 1997; 22:1741–1746. PMID: 9259785.
Full Text Links
  • KJP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr