Endocrinol Metab.  2012 Dec;27(4):276-281. 10.3803/EnM.2012.27.4.276.

APOA5 Polymorphism Is Associated with Metabolic Syndrome in Korean Postmenopausal Women

• Kim DH
• Lee SH
• Han KH
• Kim CB
• Song KY
• Cho S
• Lee KH

• KMID: 1973789
• DOI: http://doi.org/10.3803/EnM.2012.27.4.276

Abstract

BACKGROUND
Menopause is an independent risk factor in metabolic syndrome which induced an alteration of the lipid metabolism by hormonal changes. Apolipoprotein A5 gene (APOA5) was related to the regulation of triglyceride and high density lipoprotein cholesterol (HDL-C) level with biosynthesis and decomposition. This study was conducted to investigate the relationship between APOA5 polymorphism and metabolic syndrome in Korean postmenopausal women.
METHODS
This study included 307 postmenopausal women with anthropometric and biochemical measurement in 2010-2011. The polymorphism of APOA5 was analyzed by polymerase chain reaction-restriction fragment length polymorphism method with MseI restriction enzyme.
RESULTS
The metabolic syndrome prevalence with TT genotype was significantly lower than the frequency in those with TC/CC (27.09%, 38.46%, and 45.71% for TT, TC, and CC, respectively; P < 0.05). Multiple regression analysis of metabolic syndrome risk factors indicated that postmenopausal women with CC genotype had a higher risk with 3 times than that in TT genotype (P < 0.05). APOA5 C carriers showed an increased risk of triglyceride level (odd ratio, 2.93 and 1.85 for CC and TC+CC, respectively; P < 0.05). Interestingly, HDL-C was related to triglyceride directly in comparison to APOA5.
CONCLUSION
The results of this study indicate that APOA5 has an influence on serum triglyceride and HDL-C, which contribute to metabolic syndrome in Korean postmenopausal women.

Keyword

Apolipoproteins A; HDL cholesterol; Metabolic syndrome X; Single nucleotide polymorphism; Triglycerides

MeSH Terms

Apolipoproteins
Apolipoproteins A
Cholesterol
Cholesterol, HDL
Female
Genotype
Humans
Lipid Metabolism
Lipoproteins
Menopause
Metabolic Syndrome X
Polymorphism, Single Nucleotide
Prevalence
Risk Factors
Triglycerides
Apolipoproteins
Apolipoproteins A
Cholesterol
Cholesterol, HDL
Lipoproteins
Triglycerides

Figure

• 

  Fig. 1 The prevalence of metabolic syndrome according to the APOA5 isoforms. *P < 0.05 by chi-square test. APOA5, apolipoprotein A5; MetS, metabolic syndrome.

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