Tuberc Respir Dis.  2006 Dec;61(6):591-594. 10.4046/trd.2006.61.6.591.

Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Adjuvant Chemotherapy with Cisplatin plus Paclitaxel in Non-Small Cell Lung Cancer Patient

• Baek YS
• Ryu JS
• Hong SB
• Yoo SS
• Yu HK
• Son DW
• Kim L
• Kang HS
• Kim BJ
• Lee KH
• Cho JH
• Yoon YH
• Kwak SM
• Lee HL
• Kim KH

• KMID: 1970246
• DOI: http://doi.org/10.4046/trd.2006.61.6.591

Abstract

We report a case of pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following adjuvant chemotherapy. A 51-year-old woman with stage IIIA adenocarcinoma received left lower lobe lobectomy in July, 2006. And then combination chemotherapy with paclitaxel and cisplatin was given to the patient. In five days after completion of second cycle of the chemotherapy, she visited emergency room because of general weakness and seizure. Her brain MRI was shown to be no evidence of brain metastasis. Serum sodium, urine and plasma osmolarities were 117mEq/L, 589 and 244mOsm/kg, respectively. She was improved with fluid restriction. Although occurrence of SIADH following chemotherapy is rare, physician should give an attention the potential for development of SIADH in the course of chemotherapyin non-small cell lung cancer patient.

Keyword

Syndrome of inappropriate secretion of antidiuretic hormone; Chemotherapy; Non-small cell lung cancer; Seizure

MeSH Terms

Adenocarcinoma
Brain
Carcinoma, Non-Small-Cell Lung*
Chemotherapy, Adjuvant*
Cisplatin*
Drug Therapy
Drug Therapy, Combination
Emergency Service, Hospital
Female
Humans
Inappropriate ADH Syndrome
Magnetic Resonance Imaging
Middle Aged
Neoplasm Metastasis
Osmolar Concentration
Paclitaxel*
Plasma
Seizures
Sodium
Cisplatin
Paclitaxel
Sodium

Figure

• 

  Figure 1 On chest CT scan, 1.8 cm sized solitary pulmonary nodule was noted in lateral basal segment of left lower lobe at the time of diagnosis (left). No disease progression was noted on follow-up chest CT after two cycles of adjuvant chemotherapy (right).

• 

  Figure 2 Microscopic finding of adenocarcinoma of lung (H&E staining, ×200). The tumor was predominantly composed of malignant glandular cells forming irregular shaped acini and some papillae.

• 

  Figure 3 No evidence of brain metastasis was revealed on brain MRI after seizure.

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