Yeungnam Univ J Med.  2002 Dec;19(2):107-115. 10.12701/yujm.2002.19.2.107.

Comparison of Ga-67, Tl-201 and Tc-99m MIBI Imaging in Lymphoma Patients

Affiliations
  • 1Department of Nuclear Medicine, College of Medicine, Yeungnam University, Korea. Ihncho@med.yu.ac.kr
  • 2Department of Internal Medicine, College of Medicine, Yeungnam University, Korea.
  • 3Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.

Abstract

PURPOSE: Ga-67 scintigraphy has been used for the evaluation of tumors, especially lymphoma. Recently, Tl-201 and Tc-99m MIBI were also used to tumor imaging. Tl-201 and Tc-99m MIBI had better physiologic characteristics than Ga-67, so we studied 32 biopsy proven lymphoma patients (male 24, female 8, mean age 46 years) with Ga-67, Tl-201 or Tc-99m MIBI and compared the scan findings.
MATERIALS AND METHODS
Twenty-three of 32 patients were injected 74-111 MBq (2-3 mCi) of Tl-201, before chemotherapy and imaged with dual-headed SPECT (Prism 2000, Picker, USA) at 30 minutes after injection. Delayed images were obtained after 3 hr in 8 patients. Twenty seven of 32 patients were injected 740 MBq (20 mCi) of Tc-99m MIBI and imaged at 30 minutes after injection. 111-185 MBq (3-5 mCi) of Ga-67 was injected in 12 patients and imaged at 48 and 72 hours after injection. Twenty eight patients were diagnosed as non-Hodgkin's lymphoma and others were Hodgkin's lymphoma.
RESULTS
Twenty patients were positive on Tl-201 scan and 3 patients showed negative findings. One of these 3 patients, Tc-99m MIBI and Ga-67 scan were positive. Twenty two patients were positive on Tc-99m MIBI scan and 5 patients showed negative findings. One of these 5 patients, Tl-201 was positive and 2 were positive on Ga-67 scan. Ten of 12 patients showed positive findings on Ga-67 scan. The sensitivity of these agents were 83.3%, 87.0% and 81.5% for Ga-67, Tl-201 and Tc-99m MIBI, respectively. The sensitivity was highest in Tl-201 scan, but there were no significant differences among three tests. In this study, there was no significant difference of uptake ratios between early and delayed images of Tl-201.
CONCLUSION
Scintigraphy with Tl-201 and Tc-99m MIBI in lymphoma patients have similar sensitivity with Ga-67.

Keyword

Tc-99m MIBI; Tl-201; Ga-67; Lymphoma

MeSH Terms

Biopsy
Drug Therapy
Female
Hodgkin Disease
Humans
Lymphoma*
Lymphoma, Non-Hodgkin
Radionuclide Imaging
Tomography, Emission-Computed, Single-Photon
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