Ewha Med J.  1983 Sep;6(3):149-156. 10.12771/emj.1983.6.3.149.

Acute Effect of Methylprednisolone in Experimental Spinal Cord Injury

• Shin KM

• KMID: 1968489
• DOI: http://doi.org/10.12771/emj.1983.6.3.149

Abstract

It is purpose of this study to determine the benificial effect of treatment with methylprednisolone on the enhancement of Na(+).K(+)-ATPase activity and the increased ATP level during the 4 hours after a 400gm-cm injury to the spinal cord of cat. These results demonstrate that high dose(30mg/kg) of methylprednisolone can benificially enhance the activity of neuronal Na(+).K(+)-ATPase during the first 4 hour after spinal cord injury. But the enharrcement of this enzyme activity is not significantly increased with mega dose(60mg/kg) of methylprednisolone. Tissue level of ATP in the high dose-treated cat at 1 hour after trauma was significantly elevated, but those in high dose-treated cat at 4 hour and the 1 and 4 hours with mega dose-treated groups were not significantly increased. The protective effects of methylprednisolone in experimental spinal cord trauma are the enhancement of Na(+).K(+)-ATPase, inhibition of the free-radical reaction and the lipid peroxidation, the increment of neuronal activity and ATP utilization. High dose(30mg/kg) of methylprednisolone is required in order to produce the acute effect in the early phase experimental spinal cord injury.

MeSH Terms

Adenosine Triphosphate
Animals
Cats
Lipid Peroxidation
Methylprednisolone*
Neurons
Spinal Cord Injuries*
Spinal Cord*
Adenosine Triphosphate
Methylprednisolone