Ewha Med J.  2005 Sep;28(2):87-92. 10.12771/emj.2005.28.2.87.

Clinical Significance of Anti-Cyclic Citrullinated Peptide Antibodies and IgM Rheumatoid Factor in Rheumatoid Arthritis Patients

• Seo SY
• Lee J
• Kang ES

• KMID: 1964045
• DOI: http://doi.org/10.12771/emj.2005.28.2.87

Abstract

OBJECTIVES
To evaluate the clinical significances of antibodies to cyclic citrullinated peptides (anti-CCP) and IgM Rheumatoid Factor(RF) in patients with established rheumatoid arthritis.
METHODS
The subjects included 86 established RA patients according to the revised ACR criteria and 46 non-RA patients presenting joint manifestations and 61 healthy individuals as control. Anti-CCP and IgM RF were measured by ELISA and nephelometric method, respectively.
RESULTS
The sensitivity and specificity of anti-CCP were 64% and 98% and of IgM RF were 69% and 76%, respectively. Eleven (4 I %) out of 27 sero-negative RA patients had elevated anti-CCP. Combination of anti-CCP with IgM RF increased diagnostic sensitivity and specificity of RA to 81% and 99%, respectively.
CONCLUSION
Simultaneous measurement of IgM RF and anti-CCP for the initial evaluation of arthritis would increase the diagnostic efficacy of RA.

Keyword

Rheumatoid arthritis; Anti-CCP antibodies; IgM rheumatoid factor

MeSH Terms

Antibodies*
Arthritis
Arthritis, Rheumatoid*
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin M*
Joints
Peptides
Rheumatoid Factor*
Sensitivity and Specificity
Antibodies
Immunoglobulin M
Peptides
Rheumatoid Factor