J Korean Acad Periodontol.
2004 Dec;34(4):771-780. 10.5051/jkape.2004.34.4.771.
Effects of the MnCl2 on bone formation in fetal rat calvarial cell
- Affiliations
-
- 1Department of Periodontology, Chonnam National University, Korea. youngjun@jnu.ac.kr
- 2Graduate school Department of Dental science, Chonnam National University, Korea.
- 3Dental Science Research Institute, Chonnam National University, Korea.
- KMID: 1962433
- DOI: http://doi.org/10.5051/jkape.2004.34.4.771
Abstract
- Chronic exposure to high levels of manganese (Mn) leads a pronounced and debilitating disorder known as manganism. Research on the toxic manifestation of manganese have focused primarily on its neurological effects because exposure to high levels of the metal produces a distinct and irreversible extrapyramidal dysfunction resembling the dystonic movements associated with Parkinson's physiological and biochemical systems in the body. The purpose of this study is to determine the effects of Mn on mineralization in primary rat calvarial cells. The experimental groups were in concentration of 0, 10, 30 and 60 micrometer. The results were as follows: 1. ALP activity was decreased in concentration of 30 and 60 micrometer (p<0.01). 2. Bone nodule formation was depressed in concentration of 30 and 60 micrometer at day 14 and 21 (p<0.01). 3. RT-PCR results showed an altered expression of bone matrix proteins. These result suggested that manganese might decrease or alter the expression of the osteoblast phenotype.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Effect of Manganese on primary rat calvarial cell
- Effects of Ipriflavone on bone remodeling in the rat calvarial cell
- Effect of chitosan in primary rat calvarial cell
- Effects of Locally Applicated Safflower Seeds Extract on Bone Regeneration of Rat Calvarial Defects
- The effect of the Ca-P coated DBBP on osseous regeneration in the rat calvarial bone defect
