J Korean Neurosurg Soc.  2003 Sep;34(3):254-257.

Multiple Infarcts after Intra-arterial Carboplatin Therapy

• Min JH
• Kim JH
• Chung YG
• Lee NJ
• Suh JK
• Lee HK

Abstract

We report a case of multiple cerebral infarcts, which developed after intra-arterial(IA) carboplatin therapy in a patient with glioblastoma who had received surgery with conventional and intraoperative radiation therapy (IORT). A 31-year-old male patient presented with one-month history of worsening headaches and visual dimness. Seven years previously, he had been subjected to a subtotal resection of anaplastic astrocytoma in the right occipital lobe, followed by external radiation therapy with a total dose of 5580cGy. Carboplatin was given at an initial dose of 300mg/m2. Before and after the infusion of carboplatin, solumedrol(500mg/day) was given for seven days, with the dosage being gradually reduced over the next five days. In addition, 20% mannitol(100ml) was infused over a 15-minute period before chemotherapy, and the fluid volume of electrolyte was adjusted to maintain an optimal urine output. The patient underwent five cycles of IA carboplatin therapy. Careful attention should be given during IA carboplatin chemotherapy to patients who are also being treated with IORT.

Keyword

Intra-arterial chemotherapy; Carboplatin; Cerebral infarcts; Intraoperative radiation; therapy

MeSH Terms

Adult
Astrocytoma
Carboplatin*
Drug Therapy
Glioblastoma
Headache
Humans
Male
Occipital Lobe
Carboplatin