J Korean Neurosurg Soc.  1988 Aug;17(4):613-624.

Ultrastructural Changes in the Feline Basilar Artery following Experimental Subarachnoid Hemorrhage

• Min BK
• Kim YB
• Hwang SN
• Suk JS
• Choi DY
• Rhim KS

Abstract

Experimental subarachnoid hemorrhage(SAH) was produced in adult cats by injection of autologous blood(6ml) into prepontine cistern by tranclival approach and cisterna magna. The animals were sacrificed 1, 3, 5, 7 or 14 days later and basilar artery segments were prepared for electron microscopy. The following observations were made: 1) 1 to 7 days after SAH, electron micrograph showed round-shaped endothelial cells in tunica intima and disappearance of zonular occludens. Endothelial detachment from internal elastic membrane and intracytoplasmic vacuolation of endothelial cells as well as destruction of mitochondrial cirstae in tunica media. 2) 14 days after SAH, electron micrograph showed the normal findings in tunica intima and tunica media of the vessel walls. On the basis of the above findings, I found that the ultrastructural changes in the basilar arterial wall, which had presumably developed as a consequence of experimental SAH were reversible.

Keyword

Experimental subarachnoid hemorrhage; Transclival approach

MeSH Terms

Adult
Animals
Basilar Artery*
Cats
Cisterna Magna
Endothelial Cells
Humans
Membranes
Microscopy, Electron
Subarachnoid Hemorrhage*
Tunica Intima
Tunica Media